Perivascular adipose tissue-mediated arterial stiffening in aging and disease: An emerging translational therapeutic target?

Autor: Fleenor BS; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, IN, United States. Electronic address: bsfleenor@bsu.edu., Carlini NA; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, IN, United States., Ouyang A; Massachusetts General Hospital, Hebrew Senior Life, and Harvard Medical School, Boston, MA, United States., Harber MP; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, IN, United States.
Jazyk: angličtina
Zdroj: Pharmacological research [Pharmacol Res] 2022 Apr; Vol. 178, pp. 106150. Date of Electronic Publication: 2022 Mar 23.
DOI: 10.1016/j.phrs.2022.106150
Abstrakt: Cardiovascular diseases (CVD) are the leading cause of mortality in modernized societies. Arterial stiffening with aging and disease is a key pathological event leading to increased CVD morbidity and mortality. Perivascular adipose tissue (PVAT) is a fat depot not widely studied yet has direct and profound effects on arterial stiffening. Identifying PVAT as a novel therapeutic target to lower arterial stiffness and thereby CVD risk has potentially important clinical ramifications. Thus, herein, we will overview the current preclinical evidence and the associated mechanisms for PVAT to promote arterial stiffness with aging and other disease conditions. We will also discuss viable translational lifestyle and pharmacological interventions for altering PVAT function that may de-stiffen arteries. Last, the translational potential for PVAT as a therapeutic target to lower arterial stiffness and CVD risk for clinical populations will be discussed.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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