Prevalence and persistence of HPV-16 molecular variants in the anal canal of men: The HIM study.

Autor: Gonçalves MG; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil., Ferreira MT; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil., López RVM; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil., Ferreira S; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil., Sirak B; Center for Immunization and Infection Research in Cancer, and Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States., Baggio ML; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil., Lazcano-Ponce E; Center for Population Health Research, Instituto Nacional de Salud Pública, Instituto Mexicano del Seguro Social, Cuernavaca, Mexico., Nyitray AG; Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee, Wisconsin, United States; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States., Giuliano AR; Center for Immunization and Infection Research in Cancer, and Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States., Villa LL; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil; Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo -FMUSP, São Paulo, Brazil., Sichero L; Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo-ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-FMUSP HC, São Paulo, Brazil. Electronic address: laura.sichero@hc.fm.usp.br.
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2022 Apr; Vol. 149, pp. 105128. Date of Electronic Publication: 2022 Mar 09.
DOI: 10.1016/j.jcv.2022.105128
Abstrakt: Background: HPV-16 causes approximately 90% of anal canal (AC) cancers worldwide. This study aimed to evaluate the prevalence and persistence of HPV-16 genetic variants in the AC of men from three different countries (Brazil, Mexico and United States) and to further identify sociodemographic and behavioral factors associated with these infections.
Methods: Participants from the multinational prospective HPV Infection in Men (HIM) Study who had at least one HPV-16 positive AC swab were included. Characterization into HPV-16 genetic variants was successfully performed by PCR-sequencing in 95.6% (217/227) samples and these were classified into HPV-16 lineages and sublineages.
Results: We observed higher prevalence of lineage A variants, mainly from A1 sublineage, in all countries. Non-A lineage variants were mostly detected in men from Brazil, where higher diversity of sublineage variants was detected during follow-up. Compare to men detected with Non-A HPV-16 lineage variants, men infected with lineage A reported a higher lifetime number of female sexual partners. Finally, a significantly higher prevalence of Non-A lineage variants was observed among men who have sex with men (MSM) with a transient HPV-16 AC infection (p = 0.033), but no significant differences regarding variants lineages and persistence status were observed when stratified by country, self-reported ethnicity or age.
Conclusions: Our data extend previous reports which indicate that globally HPV-16 variants are unevenly distributed, and contribute further to studies of the natural history of AC HPV infections in men.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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