Reactive oxygen species-responsive RNA interference.

Autor:	Rühle J; Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger Str. 10, 91058 Erlangen, Germany. Andriy.Mokhir@fau.de., Klemt I; Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger Str. 10, 91058 Erlangen, Germany. Andriy.Mokhir@fau.de., Abakumova T; Skolkovo Institute of Science and Technology, Moscow, Russia. t.zatsepin@gmail.com., Sergeeva O; Skolkovo Institute of Science and Technology, Moscow, Russia. t.zatsepin@gmail.com., Vetosheva P; Skolkovo Institute of Science and Technology, Moscow, Russia. t.zatsepin@gmail.com., Zatsepin T; Skolkovo Institute of Science and Technology, Moscow, Russia. t.zatsepin@gmail.com.; Chemistry Department, M. V. Lomonosov Moscow State University, Leninskie gory, 1-3, Moscow 119992, Russia., Mokhir A; Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger Str. 10, 91058 Erlangen, Germany. Andriy.Mokhir@fau.de.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Mar 31; Vol. 58 (27), pp. 4388-4391. Date of Electronic Publication: 2022 Mar 31.
DOI:	10.1039/d2cc00651k
Abstrakt:	Due to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS) in vivo . These prodrugs can be used for specific targeting of ROS-rich cancer cells.
Databáze:	MEDLINE
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