| Autor: |
Ren WJ; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau 999078, China., Zhu GY; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau 999078, China., Ma Y; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Cao YH; Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China., Duan BG; Sishui Siheyuan Culture and Tourism Development Company, Ltd, Sisui 273200, China., Liu YH; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. |
| Abstrakt: |
A phytochemical investigation of Menispermum dauricum led to the isolation of five oxoisoaporphine-type alkaloids ( 1-5 ) and five aporphine-type alkaloids ( 6-10 ), including a novel oxoisoaporphine-type alkaloid: menispeimin A ( 1 ). Their structures were elucidated by spectroscopic studies including MS, 1 D and 2 D NMR, and confirmed by comparing with literature data. Among them, alkaloids 4-10 were obtained for the first time from Menispermum genus. Natural products 2 , 4 and 6 exhibited significant cytotoxic activity against A549, Bel-7402 and MCF-7 cell lines. |
