Prognostic Significance of Lobular Carcinoma In-Situ (LCIS) Diagnosed Alongside Invasive Breast Cancer.

Autor: Braasch MC; School of Medicine, The University of Kansas Health System, Kansas City, KS, USA., Amin AL; Division of Breast Surgery, Department of Surgery, The University of Kansas Health System, Kansas City, KS, USA., Balanoff CR; Division of Breast Surgery, Department of Surgery, The University of Kansas Health System, Kansas City, KS, USA., Wagner JL; Division of Breast Surgery, Department of Surgery, The University of Kansas Health System, Kansas City, KS, USA., Larson KE; Division of Breast Surgery, Department of Surgery, The University of Kansas Health System, Kansas City, KS, USA.
Jazyk: angličtina
Zdroj: Breast cancer : basic and clinical research [Breast Cancer (Auckl)] 2022 Mar 07; Vol. 16, pp. 11782234211070217. Date of Electronic Publication: 2022 Mar 07 (Print Publication: 2022).
DOI: 10.1177/11782234211070217
Abstrakt: Purpose: Women with lobular carcinoma in-situ (LCIS) have an increased risk for developing breast cancer (BC) compared with the general population. However, little is known about the clinical implication of diagnosing LCIS concurrently with an invasive breast cancer. We aimed to define the rate of LCIS diagnosed concurrently with an invasive breast cancer and investigate the risk of contralateral breast cancer (CBC) during survivorship care.
Materials and Methods: A single center retrospective review over 6 years identified women with stage I-III BC who underwent lumpectomy or unilateral mastectomy. Patients with or without concurrent LCIS were compared using Chi-squared analyses to assess for differences in clinicopathologic factors and risk of future CBC (including invasive and in-situ disease).
Results: Of 1808 patients, 16.6% (n = 301) had LCIS concurrent with their index breast cancer. Patients with LCIS had a higher rate of subsequent CBC development than those without LCIS (3.3% versus 1.0%, P  = .004). The risk ratio for patients with LCIS developing subsequent CBC compared with those without LCIS was 3.3 (95% confidence interval [CI]: 1.5-7.3).
Conclusions: Patients with LCIS diagnosed concurrently with their index breast cancer at surgery are at higher risk for subsequent CBC than those without LCIS. The evidence from this study suggest that it may be appropriate for women with LCIS diagnosed alongside an index breast cancer to consider on-going high-risk screening during survivorship care.
Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2022.)
Databáze: MEDLINE
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