SARS-CoV-2 infection after vaccination in Italian health care workers: a case report.

Autor: Cafiero C; Medical Oncology, SG Moscati Hospital, Taranto, Italy., Palmirotta R; Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', Piazza G. Cesare, 11, 70124 Bari, Italy., Micera A; Research Laboratories in Ophthalmology, IRCCS - Fondazione Bietti, via Santo Stefano Rotondo 6, 00184 Rome, Italy., Ottaiano MP; Department of Clinical Pathology and Molecular Biology, Pineta Grande Hospital Castel Volturno (CE), Castel Volturno (CE), Italy., Re A; Catholic University of Sacred Heart, Rome, Italy., Pedata F; Department of Clinical Pathology and Molecular Biology, Pineta Grande Hospital Castel Volturno (CE), Castel Volturno (CE), Italy., Costagliola D; Department of Clinical Pathology and Molecular Biology, Pineta Grande Hospital Castel Volturno (CE), Castel Volturno (CE), Italy., Ponticelli D; Pineta Grande Hospital, Castel Volturno (CE), Italy., Pisconti S; Medical Oncology, SG Moscati Hospital, Taranto, Italy., Schiavone B; Pineta Grande Hospital, Castel Volturno (CE), Italy., Benincasa G; Department of Clinical Pathology and Molecular Biology, Pineta Grande Hospital Castel Volturno (CE), Castel Volturno (CE), Italy.
Jazyk: angličtina
Zdroj: National Academy science letters. National Academy of Sciences, India [Natl Acad Sci Lett] 2022; Vol. 45 (3), pp. 249-254. Date of Electronic Publication: 2022 Mar 06.
DOI: 10.1007/s40009-022-01106-w
Abstrakt: Following the approval of COVID-19 vaccination program by EMA and national authorities, an immunization campaign started in Italy with BNT162b2mRNA vaccine, initially focused on healthcare workers. The active immunization was monitored by systemic antibody titration and continuous surveillance was guaranteed by antigenic/molecular tests on swabs. Cases of infection have been recently observed in vaccinated healthcare workers. Herein we describe an outbreak of infection occurring in five physicians out of 656 healthcare workers belonging to a private hospital, referring mild symptoms of COVID-19. Healthcare workers underwent complete vaccination and screening for antibody titration. Five out of 656 healthcare workers were tested positive for SARS-CoV-2 in nasopharyngeal swabs and referred mild COVID-19 symptoms. Molecular analyses were carried out to identify possible variants of Spike protein. Their genotyping performed on RNA extracts highlighted the presence of del69/70, N501Y, A570D, and 1841A > G (D614G) sequence variants, all indicative of VOC 202012/01-lineage B.1.1.7, suggesting a common source of infection. These cases might represent a serious emergency because outbreaks can compromise frail patients with important concomitant diseases.
Competing Interests: Conflict of interestThe authors declare no competing interest.
(© The Author(s) 2022.)
Databáze: MEDLINE
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