| Autor: |
Maness PF, Sorge LK, Fults DW |
| Jazyk: |
angličtina |
| Zdroj: |
Developmental biology [Dev Biol] 1986 Sep; Vol. 117 (1), pp. 83-9. |
| DOI: |
10.1016/0012-1606(86)90350-7 |
| Abstrakt: |
The expression of the normal cellular src protein (pp60c-src) was investigated in the early chick embryo during gastrulation and neurulation by immunoperoxidase staining using antisera, raised against bacterially expressed pp60v-src, that recognizes pp60c-src specifically in normal cells. During gastrulation pp60c-src immunoreactivity appeared primarily in the neural ectoderm and was much less prominent in the mesoderm, endoderm, and nonneural ectoderm. During neurulation pp60c-src immunoreactivity began to disappear from the wall of the closing neural tube so that by the completion of neural tube closure no specific pp60c-src immunoreactivity appeared in any of the neuroepithelial cells composing the neural tube. These studies reveal a developmental phase of pp60c-src expression even earlier than reported previously, when neuroepithelial cells of later embryos undergo terminal neuronal differentiation. These findings raise the possibility that pp60c-src may mediate two different differentiation signals in the neuronal lineage. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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