Clinical profile, risk factors and outcomes of ric COVID-19: a retrospective cohort multicentre study in Saudi Arabia.

Autor:	Albuali WH; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., AlGhamdi AA; Department of Family and Community Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Aldossary SJ; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., AlHarbi SA; Department of Pediatrics, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Pediatrics, Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia., Al Majed SI; Department of Pediatrics, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia., Alenizi A; Pediatric Pulmonology and Sleep Medicine Department, King Saud Medical City, Riyadh, Saudi Arabia., Al-Qahtani MH; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; Department of Pediatrics, Imam Abdulrahman Bin Faisal University College of Medicine, Dammam, Saudi Arabia., Lardhi AA; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Al-Turki SA; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., AlSanea AS; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Bubshait DK; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Kobeisy SA; Department of Pediatrics, Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia., Herzallah NH; Department of Pediatrics, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia., Alqarni WA; Department of Pediatrics, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia., AlHarbi AH; Pediatric Pulmonology and Sleep Medicine Department, King Saud Medical City, Riyadh, Saudi Arabia., Albuali HW; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Aldossary BJ; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., AlQurashi FO; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia faisal.alqurashi@yahoo.com.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Yousef AA; Department of Pediatrics, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Mar 11; Vol. 12 (3), pp. e053722. Date of Electronic Publication: 2022 Mar 11.
DOI:	10.1136/bmjopen-2021-053722
Abstrakt:	Objective: To describe the risk factors, clinical profile and outcomes of COVID-19 in the paediatric population. Design: Multicentre, retrospective observational study. Setting: Four tertiary hospitals in Saudi Arabia. Patients: We recruited 390 paediatric patients aged 0-18 years who presented from March to December 2020 and tested positive for COVID-19 on PCR. Main Outcome Measures: We retrospectively analysed medical records for sociodemographics, health indicators, clinical presentations, laboratory findings, clinical complications, and outcomes. Results: The mean participant age was 5.66±4.90 years, and the mean hospital stay was 2.17±3.48 days. Forty patients, mostly school-aged children (16, 40.00%; p=0.005) and children with comorbidities (25, 62.50%; p<0.001), received more than just supportive care. Complications were seen in 15 (3.9%) patients, bacterial infection being the most common (6, 40.00%). Patients presented with dyspnoea (OR 6.89; 95% CI 2.89 to 20.72), abnormal chest radiographs (OR 6.11; 95% CI 1.26 to 29.38), lethargy (OR 9.04; 95% CI 2.91 to 28.06) and elevated ferritin (OR 14.21; 95% CI 4.18 to 48.37) and D-dimer (OR 48.40; 95% CI 14.32 to 163.62), with higher odds of developing complications. The odds of paediatric intensive care unit (ICU) admission were higher for patients with dyspnoea (adjusted OR 4.66; 95% CI 1.24 to 17.50) and elevated white blood cell count (adjusted OR 3.54; 95% CI 1.02 to 12.30). Conclusions: COVID-19 complications were limited among our patients. However, dyspnoea, abnormal chest radiographs, lethargy and elevated ferritin and D-dimer were associated with an increased risk of complications. Dyspnoea, leucocytosis, comorbidities and abnormal chest radiographs at presentation increased the risk of ICU admission. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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