| Autor: |
Laube F, Blech W, Schröder D, Besch W, Hildebrandt W, Hahn HJ |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental and clinical endocrinology [Exp Clin Endocrinol] 1986 Jun; Vol. 87 (1), pp. 69-78. |
| DOI: |
10.1055/s-0029-1210525 |
| Abstrakt: |
We investigated the effect of Cyclosporin A (100 ng/ml - 12000 ng/ml) on functional parameters of the endocrine pancreas in vitro. The insulin secretion of isolated islets in response to a variety of secretory stimulators is characterized by minimal alteration occasionally observed in the presence of very high Cyclosporin A concentrations. Cyclosporin A did not alter the glucose-induced biphasic insulin secretion, nor the arginine-stimulated glucagon secretion of the perfused rat pancreas. Exposure of isolated islets to 2000 ng Cyclosporin A/ml for 3 weeks resulted in a minimal decrease of insulin content and a marked reduction of glucagon content, which were not accompanied by drastic alterations of insulin secretion. Scanning electron micrographs of these Cyclosporin A-treated islets did not differ from cultured control islets. The results let us assume that Cyclosporin A exerts no toxic effects on the endocrine pancreas in vitro, when exposed to concentrations greater than or equal to 2000 ng/ml. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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