The Puzzle of Functional Recovery in Schizophrenia-Spectrum Disorders-Replicating a Network Analysis Study.

Autor:	Moura BM; Clínica Universitária de Psiquiatria e Psicologia Médica, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.; Department of Psychiatry and Mental Health, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands., Isvoranu AM; Department of Psychology, Psychological Methods, University of Amsterdam, Amsterdam, The Netherlands., Kovacs V; Department of Psychiatry, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Amsterdam, The Netherlands., Van Rooijen G; Department of Psychiatry, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Psychiatry, Dijklander Ziekenhuis, Hoorn, The Netherlands., Van Amelsvoort T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands., Simons CJP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.; GGzE Institute for Mental Health Care Eindhoven, Eindhoven, The Netherlands., Bartels-Velthuis AA; University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, Groningen, The Netherlands., Bakker PR; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.; Research Department, Arkin Institute for Mental Health, Amsterdam, The Netherlands., Marcelis M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.; GGzE Institute for Mental Health Care Eindhoven, Eindhoven, The Netherlands., De Haan L; Department of Psychiatry, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Research Department, Arkin Institute for Mental Health, Amsterdam, The Netherlands., Schirmbeck F; Department of Psychiatry, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Research Department, Arkin Institute for Mental Health, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin [Schizophr Bull] 2022 Jun 21; Vol. 48 (4), pp. 871-880.
DOI:	10.1093/schbul/sbac018
Abstrakt:	Background and Hypothesis: Recovery from psychosis is a complex phenomenon determined by an array of variables mutually impacting each other in a manner that is not fully understood. The aim of this study is to perform an approximated replication of a previous network analysis study investigating how different clinical aspects-covering psychopathology, cognition, personal resources, functional capacity, and real-life functioning-are interrelated in the context of schizophrenia-spectrum disorders. Study Design: A sample of 843 subjects from a multisite cohort study, with the diagnosis of a schizophrenia-spectrum disorder, was used to estimate a network comprising 27 variables. The connectivity and relative importance of the variables was examined through network analysis. We used a quantitative and qualitative approach to infer replication quality. Study Results: Functional capacity and real-life functioning were central and bridged different domains of the network, in line with the replicated study. Neurocognition, interpersonal relationships, and avolition were also key elements of the network, in close relation to aspects of functioning. Despite significant methodological differences, the current study could substantially replicate previous findings. Conclusions: Results solidify the network analysis approach in the context of mental disorders and further inform future studies about key variables in the context of recovery from psychotic disorders. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.)
Databáze:	MEDLINE
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