Changes in renal function increase the need for advanced ventilatory support and increase the risk of mortality in critically ill patients with COVID-19.

Autor: De Morais NM; Multicentric Postgraduate Program in Physiological Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil., De Morais Leone LCC; Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil., De Almeida VD; Multicentric Postgraduate Program in Physiological Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil., De Andrade MF; Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil., Do Nascimento EGC; Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil.; Postgraduate Program in Health and Society, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil., Fernandes JV; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59078-970, Brazil., Bezerra CM; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59078-970, Brazil., De Medeiros Fernandez TAA; Multicentric Postgraduate Program in Physiological Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil.; Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil.; Postgraduate Program in Health and Society, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil.
Jazyk: angličtina
Zdroj: Biomedical reports [Biomed Rep] 2022 Mar; Vol. 16 (3), pp. 18. Date of Electronic Publication: 2022 Jan 31.
DOI: 10.3892/br.2022.1501
Abstrakt: In addition to respiratory failure, another important outcome presented by patients hospitalized with coronavirus disease 2019 (COVID-19) is renal failure, which is related to increased severity of infection and a greater risk of mortality. Severity is often represented by the need for respiratory and/or life support, which can range from oxygen therapy to invasive mechanical ventilation. This study aimed to determine the association between the degree of renal and inflammatory impairment in patients with the need for advanced respiratory support and mortality. Included in the present study were 79 critically ill patients with COVID-19 on different days, who required a nasal cannula and/or orotracheal intubation. Data from laboratory tests, arterial blood gases and information on their clinical evolution were collected. The results obtained showed that the biochemical markers of renal function, as well as the inflammatory markers and the partial pressure of carbon dioxide, were significantly increased in patients who succumbed to the infection. Similarly, these markers were higher amongst patients who required increased respiratory assistance.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
Databáze: MEDLINE
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