JAK-STAT core cancer pathway: An integrative cancer interactome analysis.

Autor: Erdogan F; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Radu TB; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria., Qadree AK; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada., Israelian J; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Valent P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Mustjoki SM; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Hematology Research Unit, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Herling M; Department of Hematology, Cellular Therapy, and Hemostaseology, University of Leipzig, Leipzig, Germany., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Jazyk: angličtina
Zdroj: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Apr; Vol. 26 (7), pp. 2049-2062. Date of Electronic Publication: 2022 Mar 01.
DOI: 10.1111/jcmm.17228
Abstrakt: Through a comprehensive review and in silico analysis of reported data on STAT-linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for therapeutic intervention to disrupt critical pathways and addictions to hyperactive JAK/STAT in neoplastic states. Although all STATs follow a similar molecular activation pathway, STAT1, STAT2, STAT4 and STAT6 exert specific biological profiles associated with a more restricted pattern of activation by cytokines. STAT3 and STAT5A as well as STAT5B have pleiotropic roles in the body and can act as critical oncogenes that promote many processes involved in cancer development. STAT1, STAT3 and STAT5 also possess tumour suppressive action in certain mutational and cancer type context. Here, we demonstrated member-specific STAT activity in major cancer types. Through systems biology approaches, we found surprising roles for EGFR family members, sex steroid hormone receptor ESR1 interplay with oncogenic STAT function and proposed new drug targeting approaches of oncogenic STAT pathway addiction.
(© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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