| Autor: |
Feodorova VA; Federal Research Center for Virology and Microbiology, Branch in Saratov, 410028 Saratov, Russia., Saltykov YV; Federal Research Center for Virology and Microbiology, Branch in Saratov, 410028 Saratov, Russia., Kolosova AA; Federal Research Center for Virology and Microbiology, Branch in Saratov, 410028 Saratov, Russia., Rubanik LV; Republican Research and Practical Center for Epidemiology and Microbiology, 220114 Minsk, Belarus., Poleshchuk NN; Republican Research and Practical Center for Epidemiology and Microbiology, 220114 Minsk, Belarus., Motin VL; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA. |
| Abstrakt: |
Chlamydia trachomatis (CT) is a major cause of sexually transmitted diseases worldwide. The multilocus sequence typing (MLST) of clinical samples from random heterosexual chlamydia patients who were either asymptomatic or reported clinical manifestations of genital chlamydiosis ( n = 63) in each of the seven major regions of the Republic of Belarus in 2017-2018 revealed 12 different CT sequence types (STs). We found seven known STs, ST4, ST6, ST9, ST13, ST38, ST95 and ST110, and five novel variants, namely ST271-ST275, which have not been detected elsewhere thus far. The ST4 variant was predominant (27/63, 42.9%) and detected in six out of seven regions. The two most common STs, ST9 and ST13, were regularly seen in four out of seven regions. In contrast, the remaining STs, ST6, ST38, ST95, ST110, and novel STs271-275, surfaced randomly in different parts of the country. The emergence of novel STs was registered in two regions, namely Minsk (ST271 and ST275) and Brest (ST271, ST272, ST273, and ST274). All the STs of detected CT strains were clustered into two Groups, I and III, which are characteristic of CT urogenital strains. No STs typical for Group II, specific to the LGV strains, were revealed. Our study contributes to better understanding the genetic diversity and molecular evolution of CT, one of the most important pathogens in public health worldwide. |
