| Autor: |
Gohar EY; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., De Miguel C; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Obi IE; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Daugherty EM; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Hyndman KA; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Becker BK; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Jin C; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Sedaka R; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Johnston JG; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Liu P; Department of Physiology Medical College of Wisconsin Milwaukee WI., Speed JS; Department of Physiology University of Mississippi Medical Center Jackson MS., Mitchell T; Department of Urology University of Alabama at Birmingham AL., Kriegel AJ; Department of Physiology Medical College of Wisconsin Milwaukee WI., Pollock JS; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL., Pollock DM; Section of Cardio-Renal Physiology & Medicine Division of Nephrology Department of Medicine University of Alabama at Birmingham AL. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Heart Association [J Am Heart Assoc] 2022 Mar; Vol. 11 (5), pp. e020450. Date of Electronic Publication: 2022 Feb 22. |
| DOI: |
10.1161/JAHA.120.020450 |
| Abstrakt: |
Background Premenopausal women are less likely to develop hypertension and salt-related complications than are men, yet the impact of sex on mechanisms regulating Na + homeostasis during dietary salt challenges is poorly defined. Here, we determined whether female rats have a more efficient capacity to acclimate to increased dietary salt intake challenge. Methods and Results Age-matched male and female Sprague Dawley rats maintained on a normal-salt (NS) diet (0.49% NaCl) were challenged with a 5-day high-salt diet (4.0% NaCl). We assessed serum, urinary, skin, and muscle electrolytes; total body water; and kidney Na + transporters during the NS and high-salt diet phases. During the 5-day high-salt challenge, natriuresis increased more rapidly in females, whereas serum Na + and body water concentration increased only in males. To determine if females are primed to handle changes in dietary salt, we asked the question whether the renal endothelin-1 natriuretic system is more active in female rats, compared with males. During the NS diet, female rats had a higher urinary endothelin-1 excretion rate than males. Moreover, Ingenuity Pathway Analysis of RNA sequencing data identified the enrichment of endothelin signaling pathway transcripts in the inner medulla of kidneys from NS-fed female rats compared with male counterparts. Notably, in human subjects who consumed an Na + -controlled diet (3314-3668 mg/day) for 3 days, women had a higher urinary endothelin-1 excretion rate than men, consistent with our findings in NS-fed rats. Conclusions These results suggest that female sex confers a greater ability to maintain Na + homeostasis during acclimation to dietary Na + challenges and indicate that the intrarenal endothelin-1 natriuretic pathway is enhanced in women. |
| Databáze: |
MEDLINE |
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