Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease.

Autor:	Frantz WT; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; Department of Molecular, Cellular and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Ceol CJ; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; Department of Molecular, Cellular and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: craig.ceol@umassmed.edu.
Jazyk:	angličtina
Zdroj:	The Journal of investigative dermatology [J Invest Dermatol] 2022 Mar; Vol. 142 (3 Pt A), pp. 499-506.e1.
DOI:	10.1016/j.jid.2021.10.016
Abstrakt:	Skin diseases affect nearly one third of the world's population. Disease types range from oncologic to inflammatory, and outcomes can be as severe as death and disfigurement. Although many skin diseases have been modeled in murine models, the advantages of zebrafish models have led to recent increasing use in modeling human disease. Their rapid development, comparable skin architecture, tractable genetics, unparalleled optical properties, and straightforward drug screens make them an excellent model to study skin disease. In this review, we discuss the attributes of the zebrafish model system as well as current zebrafish models for dermatologic diseases, including melanoma, squamous cell carcinoma, vitiligo, epidermal bullosa, psoriasis, and wounding. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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