aPDT for oral decontamination of hospitalized patients with COVID 19.

Autor: Morimoto S; School of Dentistry, Ibirapuera University (UNIB), São Paulo, SP, Brazil. Electronic address: susanamorimoto@gmail.com., Rosin JLA; CAES - Military Police of São Paulo State, São Paulo, SP, Brazil., Matuck BF; Department of Pathology, School of Medicine, University of São Paulo (USP), São Paulo, SP, Brazil., Schröter G; Department of Stomatology, School of Dentistry, University of São Paulo (USP), São Paulo, SP, Brazil., Rodrigues MFSD; Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University (UNINOVE), São Paulo, SP, Brazil., Ramalho KM; School of Dentistry, Ibirapuera University (UNIB), São Paulo, SP, Brazil., Raggio DP; Department of Pediatrics, School of Dentistry, University of São Paulo (USP), São Paulo, SP, Brazil., Moreira MS; School of Dentistry, Ibirapuera University (UNIB), São Paulo, SP, Brazil; Department of Stomatology, School of Dentistry, University of São Paulo (USP), São Paulo, SP, Brazil., da Silva LFF; Department of Pathology, School of Medicine, University of São Paulo (USP), São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2022 Jun; Vol. 38, pp. 102762. Date of Electronic Publication: 2022 Feb 16.
DOI: 10.1016/j.pdpdt.2022.102762
Abstrakt: Emerging variants of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) may have an impact on the virus's transmissibility and pathogenicity and an increased risk of reinfection. Antimicrobial photodynamic therapy (aPDT) is a promising technique to decontaminate the oral cavity to minimize and inactivate microorganisms' load. This article reports through a case series, a proposal for efficient oral decontamination for hospitalized patients with COVID 19 using aPDT. Samples of oral tissues were obtained after aPDT and analyzed using two methods of RT-qPCR to elucidate qualitative and quantitative viral profiles of SARS-CoV-2 RNA in the oral cavity. There was a reduction of viral load in the oral cavity immediately or one hour after the use of aPDT. This method could be a good option to decontaminate the oral cavity to minimize and inactivate microorganism load.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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