The SARS-CoV-2 Mu variant should not be left aside: It warrants attention for its immuno-escaping ability.

Autor: Pascarella S; Dipartimento di Scienze biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, Roma, Italy., Bianchi M; Dipartimento di Scienze biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, Roma, Italy., Giovanetti M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.; Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico di Roma, Rome, Italy.; Federal University of Minas Gerais, Belo Horizonte, Brazil., Narzi D; Department of Physical and Chemical Sciences, University of L'Aquila, L'Aquila, Italy., Cauda R; Policlinico Agostino Gemelli, Roma, Italy., Cassone A; Center of Genomics, Genetics and Biology, Siena, Italy., Ciccozzi M; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2022 Jun; Vol. 94 (6), pp. 2479-2486. Date of Electronic Publication: 2022 Feb 28.
DOI: 10.1002/jmv.27663
Abstrakt: The COVID-19 pandemic continues to have a threatening impact on a global scale, largely due to the emergence of newly SARS-CoV-2 variants. The Mu (PANGO lineage B.1.621), was first identified in Colombia in January 2021 and was classified as a variant of interest (VOI) in August 2021, due to a constellation of mutations that likely-mediate an unexpectedly enhanced immune resistance to inactivated vaccine-elicited antibodies. Despite recent studies suggesting that the Mu variant appears to have less infectivity than the Delta variant, here we examined the structural effect of the Mu spike protein mutations and predicted the potential impact on infectivity of the Mu variant compared with the Delta and Delta plus spike protein.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: