Genetics of inherited thrombocytopenias.
| Autor: | Warren JT; Division of Hematology-Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO., Di Paola J; Division of Hematology-Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Blood [Blood] 2022 Jun 02; Vol. 139 (22), pp. 3264-3277. |
| DOI: | 10.1182/blood.2020009300 |
| Abstrakt: | The inherited thrombocytopenia syndromes are a group of disorders characterized primarily by quantitative defects in platelet number, though with a variety demonstrating qualitative defects and/or extrahematopoietic findings. Through collaborative international efforts applying next-generation sequencing approaches, the list of genetic syndromes that cause thrombocytopenia has expanded significantly in recent years, now with over 40 genes implicated. In this review, we focus on what is known about the genetic etiology of inherited thrombocytopenia syndromes and how the field has worked to validate new genetic discoveries. We highlight the important role for the clinician in identifying a germline genetic diagnosis and strategies for identifying novel causes through research-based endeavors. (© 2022 by The American Society of Hematology.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|