Efficacy of Hexetidine, Thymol and Hydrogen Peroxide-Containing Oral Antiseptics in Reducing Sars-Cov-2 Virus in the Oral Cavity: A Pilot Study.

Autor:	Ogun SA; Neurology Unit, Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Erinoso O; Lagos State University Teaching Hospital, Lagos, Nigeria., Aina OO; Nigerian Institute of Medical Research, Lagos, Nigeria., Ojo OI; Lagos State University Teaching Hospital, Lagos, Nigeria., Adejumo O; Mainland Hospital, Yaba, Lagos, Nigeria., Adeniran A; Lagos State University Teaching Hospital, Lagos, Nigeria., Bowale A; Mainland Hospital, Yaba, Lagos, Nigeria., Olaniyi CA; Lagos State University Teaching Hospital, Lagos, Nigeria., Adedoyin BM; National Orthopaedic Hospital, Igbobi, Lagos State, Nigeria., Mutiu B; Lagos State Biobank, Nigeria., Saka B; Lagos State Biobank, Nigeria., Oshinaike O; Lagos State University Teaching Hospital, Lagos, Nigeria., Arabambi W; Neurology Unit, Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Adejumo F; Mainland Hospital, Yaba, Lagos, Nigeria., Shuaib O; Lagos State University Teaching Hospital, Lagos, Nigeria., Salmon AO; Lagos State University Teaching Hospital, Lagos, Nigeria., Abdur-Razzaq H; Lagos State Ministry of Health, Lagos, Nigeria., Njokanma OF; Lagos State University Teaching Hospital, Lagos, Nigeria., Ojini O; College of Medicine, University of Lagos, Lagos, Nigeria., Ogboye O; Lagos State Ministry of Health, Lagos, Nigeria., Lajide O; Lagos State Ministry of Health, Lagos, Nigeria., Wright KO; Lagos State University Teaching Hospital, Lagos, Nigeria., Osibogun A; College of Medicine, University of Lagos, Lagos, Nigeria., Abayomi A; Lagos State Ministry of Health, Lagos, Nigeria.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2022 Jan 31; Vol. 39 (1), pp. 83-89.
Abstrakt:	Background: Studies have demonstrated the role of sputum as a site of severe acute respiratory syndrome-coronavirus-2 (SARSCoV-2) transmission. However, there is limited literature on the virucidal efficacy of oral antiseptics against SARS-CoV-2 virus. This study investigated the virucidal efficacy of three oral-antiseptics compared to a placebo-control in the sputum of SARS-CoV-2 infected individuals. Methodology: A pilot study of adults with SARS-CoV-2 positive results, as determined by reverse transcription-polymerase chain reaction (RT-PCR) of <7 days. The oral antiseptics investigated were: Hexetidine (0.1% w/v); Thymol (0.063% w/v) and H2O2(1.5%) compared to de-mineralized sterile water (Placebo-control). The primary outcome measure was the proportion of negative RT-PCR results at 15-mins, 30-mins, 1-hour, 2-hours and 4-hours After Oral antiseptics Interventions (AOI) compared to the placebo-control. Statistical analysis was done using STATA 15.0 software with p-values of <0.05 considered statistically significant. Results: Data from a total of 66 participants that were RT-PCR SARS-CoV-2 positive at baseline (0-min) was analysed. At 15-mins AOI, the highest proportion of negativation from sputum samples was observed in the Hexedine group, with 69.2% of the baseline PCR positive cases converting to negative compared to 46.7% in the placebo-control group. In addition, H2O2 demonstrated efficacy at 2-hours AOI compared to placebo-control (62.5% vs 37.5% respectively) and other oral-antiseptics. Across all time-points, the oral-antiseptic groups compared to the placebo-control group, there was no statistically significant difference in the proportion of sputum samples which converted to a negative status (p>0.05). Conclusion: The findings in this study suggest there was no significant difference in the proportion of participants who converted to a negative sputum status across the treatment groups at various time points. Future studies could compare the cycle threshold (ct) viral titre values of sputum samples to determine quantitative differences. Competing Interests: The Authors declare that no competing interest exists. (Copyright © 2022 by West African Journal of Medicine.)
Databáze:	MEDLINE
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