| Autor: |
Aguilar Pérez M; Neuroradiological Clinic, Katharinenhospital Stuttgart, 70174 Stuttgart, Germany., Henkes H; Neuroradiological Clinic, Katharinenhospital Stuttgart, 70174 Stuttgart, Germany.; Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany., Kurre W; Department of Radiology and Neuroradiology, Klinikum Passau, 94032 Passau, Germany., Bleise C; Department of Interventional Neuroradiology, Clínica La Sagrada Familia, Buenos Aires C1426EOB, Argentina., Lylyk PN; Department of Interventional Neuroradiology, Clínica La Sagrada Familia, Buenos Aires C1426EOB, Argentina., Lundquist J; Department of Interventional Neuroradiology, Clínica La Sagrada Familia, Buenos Aires C1426EOB, Argentina., Turjman F; Department of Interventional Neuroradiology, Hôpital Pierre Wertheimer, 69500 Lyon, France., Alhazmi H; Department of Interventional Neuroradiology, Hôpital Pierre Wertheimer, 69500 Lyon, France., Loehr C; Department of Radiology and Neuroradiology, Klinikum Vest Knappschaftskrankenhaus Recklinghausen, 45657 Recklinghausen, Germany., Felber S; Department of Diagnostic and Interventional Radiology and Neuroradiology, Gemeinschaftsklinikum Mittelrhein, 56068 Koblenz, Germany., Deutschmann H; Department of Radiology, Clinical Division of Neuroradiology, Vascular and Interventional Radiology, Medical Universtity Graz, 8063 Graz, Austria., Lowens S; Department of Radiology, Klinikum Osnabrück, 49076 Osnabruck, Germany., Delehaye L; Unit of Interventional Neuroradiology, Ospedale San Giovanni Bosco, 80144 Napoli, Italy., Möhlenbruch M; Department of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Hattingen J; Institute of Neuroradiology, KRH Klinikum Nordstadt, 30167 Hannover, Germany., Lylyk P; Department of Interventional Neuroradiology, Clínica La Sagrada Familia, Buenos Aires C1426EOB, Argentina. |
| Abstrakt: |
Coil embolization has become a well-established option for the treatment of intracranial aneurysms. Yet, wide-neck bifurcation aneurysms (WNBAs) remain a challenge. The pCONUS is the first generation of a stent-like implant for the bridging of WNBAs to enable coiling. The pToWin study was a prospective, single-arm, multicenter study conducted to analyze the safety and efficacy of the pCONUS in the treatment of WNBAs. The primary effectiveness endpoint was the rate of adequate occlusion of the aneurysm at 3-6 and 7-12 months. The primary safety endpoint was the occurrence of major ipsilateral stroke or neurological death during the follow-up. A total of 115 patients were included. Aneurysm locations were the middle cerebral artery in 52 (45.2%), the anterior communicating artery in 35 (30.4%), the basilar artery in 23 (20%), the internal carotid artery terminus in three (2.6%), and the pericallosal artery in two (1.7%) patients. Treatment was successfully performed in all but one patient. The morbi-mortality rate was 1.9% and 2.3% at 3-6 and 7-12 months, respectively. Of the aneurysms, 75.0% and 65.6% showed adequate occlusion at 3-6 and 7-12 months, respectively. pCONUS offers a safe and reasonably effective treatment of WNBAs, demonstrated by acceptable adequate aneurysm occlusion and low rates of adverse neurologic events. |
