Larvicidal activity against Aedes aegypti and molecular docking studies of compounds extracted from the endophytic fungus Aspergillus sp. isolated from Bertholletia excelsa Humn. & Bonpl.

Autor: Araújo IF; Biocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil., Marinho VHS; Biocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil., Sena IDS; Biocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil., Curti JM; Biocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil., Ramos RDS; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá, AP, 68902-280, Brazil., Ferreira RMA; Arthropod Laboratory, Collegiate of Biology, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil., Souto RNP; Arthropod Laboratory, Collegiate of Biology, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil., Ferreira IM; Biocatalysis and Applied Organic Synthesis Laboratory, Collegiate of Chemistry, Federal University of Amapá, Rod. JK, KM 02, Macapá, Amapá, 68902-280, Brazil. irlon.ferreira@gmail.com.
Jazyk: angličtina
Zdroj: Biotechnology letters [Biotechnol Lett] 2022 Mar; Vol. 44 (3), pp. 439-459. Date of Electronic Publication: 2022 Feb 11.
DOI: 10.1007/s10529-022-03220-7
Abstrakt: Endophytic fungi are microorganisms capable of colonizing the interior of plant tissues without causing damage to them. The study of the secondary metabolites produced by their vast biodiversity fungal is relevant for the discovery of new products for biotechnological and agrochemical applications. In addition, extract of the endophytic fungus Aspergillus sp., isolated from the almonds of Bertholletia excelsa Humn & Bonlp collected in the Brazilian Amazon, oviposition deterrent, and larvicidal activity of against Aedes aegypti. In the oviposition deterrence test was observed that females able to lay eggs preferred the control oviposition sites (46.6%). Furthermore, the extract showed larvicidal activity with LC50 26.86 µg/mL at 24 h and 18.75 µg/mL at 48 h. Molecular docking studies showed the compound Aspergillol B a potent larvicide by to inhibit the acetylcholinesterase enzyme (- 7.74 kcal/mol). These results indicate that compounds from secondary metabolites of Aspergillus sp., isolated from almonds of B. excelsa, are useful biological potential against vectors A. aegypti.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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