Polymorphisms in CYP1B1 gene and the risk of suffering Primary Open-Angle Glaucoma: Systematic review and meta-analysis.

Autor:	Calero-Dueñas N; 16383Bellvitge University Hospital, Hospitalet de Llobregat, Spain., Mateos-Olivares M; Departament of Ophthalmology, 16238Hospital Universitario de Valladolid, Valladolid, Spain.; 537068Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain., Ussa F; 537068Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.; Department of Ophthalmology, 156705The James Cook University Hospital, Middlesbrough, UK., Juberías JR; Departament of Ophthalmology, 16238Hospital Universitario de Valladolid, Valladolid, Spain.; 537068Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain., Marcos M; Department of Internal Medicine, University Hospital of Salamanca-IBSAL; 37479University of Salamanca, Salamanca, Spain., Pastor-Idoate S; Departament of Ophthalmology, 16238Hospital Universitario de Valladolid, Valladolid, Spain.; 537068Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.; Cooperative Health Network for Research in Ophthalmology (Oftared), National Institute of Health Carlos III, ISCIII, Madrid, Spain., Usategui-Martín R; 537068Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.; Cooperative Health Network for Research in Ophthalmology (Oftared), National Institute of Health Carlos III, ISCIII, Madrid, Spain.; Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Jazyk:	angličtina
Zdroj:	European journal of ophthalmology [Eur J Ophthalmol] 2022 Jul; Vol. 32 (4), pp. 1841-1849. Date of Electronic Publication: 2022 Feb 09.
DOI:	10.1177/11206721221077621
Abstrakt:	Purpose: It had been reported that mutations in CYP1B1 gene probably play an important role in the pathogenesis of primary open angle glaucoma (POAG) but the existing genetic association studies show contradictory results. Thus, the objective of our study was to perform a systematic review and meta-analysis to characterize more precisely the potential association between given polymorphisms in CYP1B1 gene and the risk of suffering POAG. Methods: A systematic review of studies that related the risk of carrying CYP1B1 gene polymorphisms with POAG development was conducted. We selected 19 case-control studies including 3855 POAG patients and 4125 control subjects in our meta-analyses. A random effects model was used. Sensitivity analysis and assessment of bias were also included. Results: The prevalence of CYP1B1 gene polymorphisms were significantly more frequent among POAG patients compared to all controls (OR = 2.91, 95% CI = 1.37 - 6.21; P = 0.006). Moreover, their prevalence was significantly higher in juvenile-onset patients than in adult-onset ones (OR = 2.27, 95% CI = 1.20-4.28; P = 0.001). Conclusion: The results of this meta-analysis uphold that being a carrier of polymorphic genetic variants in CYP1B1 gene would increase the risk of POAG, especially the juvenile onset.
Databáze:	MEDLINE
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