Erythroblastic synartesis associated with lymphoproliferative disorder: There can be more than meets the eye.

Autor: Mettler C; Timone Hospital, Internal Medicine Department, AP-HM, Marseille, France. Electronic address: camille.mettler@ap-hm.fr., Petit C; Timone Hospital, Internal Medicine Department, AP-HM, Marseille, France., Ernest V; Timone Hospital, Internal Medicine Department, AP-HM, Marseille, France., Asli B; Sauvegarde Clinic, Internal Medicine Department, Lyon, France., Daniel MT; Saint-Louis Hospital, Hematology Laboratory, AP-HP, Paris, France., Mathis S; Saint-Louis Hospital, Hematology Laboratory, AP-HP, Paris, France., Zini JM; Saint-Louis Hospital, Immuno-Hematology Department, AP-HP, Paris, France., Faucher B; Timone Hospital, Internal Medicine Department, AP-HM, Marseille, France., Ebbo M; Timone Hospital, Internal Medicine Department, AP-HM, Marseille, France., Legendre P; Foch Hospital, Internal Medicine Department, Suresnes, France., Malphettes M; Saint-Louis Hospital, Immuno-Hematology Department, AP-HP, Paris, France.
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2022 Mar; Vol. 236, pp. 108951. Date of Electronic Publication: 2022 Feb 05.
DOI: 10.1016/j.clim.2022.108951
Abstrakt: Erythroblastic synartesis is a rare cause of acquired dyserythropoiesis. Only 9 cases have been previously reported. We hereby report 3 cases of patients diagnosed with erythroblastic synartesis associated with monoclonal immunoglobulin and an overt malignant lymphoid disorder. A different B-cell clone may produce the monoclonal immunoglobulin, forming a biclonal disorder. In light of these data and literature review, treatment targeting the paraprotein seems to be efficient to control synartesis and correct anemia. In the case of monoclonal gammapathy associated with chronic lymphocytic leukemia, therapeutics should be adapted to control both chronic lymphocytic leukemia and monitored monoclonal immunoglobulin titer.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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