Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum.

Autor:	Muralidharan AR; Singapore Eye Research Institute, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore., Low SWY; Singapore Eye Research Institute, Singapore., Lee YC; Singapore Eye Research Institute, Singapore., Barathi VA; Singapore Eye Research Institute, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Saw SM; Singapore Eye Research Institute, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Milea D; Singapore Eye Research Institute, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore.; Singapore National Eye Centre, Singapore., Najjar RP; Singapore Eye Research Institute, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2022 Feb 01; Vol. 63 (2), pp. 16.
DOI:	10.1167/iovs.63.2.16
Abstrakt:	Purpose: The purpose of this study was to evaluate the impact of full-spectrum light-emitting diodes mimicking sunlight (Sunlike LEDs) on ocular growth and refractive error development in a chicken model of myopia. Methods: One-day old chicks (n = 39) were distributed into 3 groups and raised for 28 days in isoluminant (approximately 285 lux) fluorescent (n = 18, [FL-4000], correlated color temperature [CCT] = 4000 K) or Sunlike LED (n = 12, [SL-4000], CCT = 4000 K; n = 9, [SL-6500], CCT = 6500 K) white lighting environments. Form-deprivation myopia was induced monocularly from day 1 post-hatching (D1) until D14. On D14, form deprivation was halted and the recovery of form-deprived (FD) eyes was monitored until D28. Axial length (AL), refraction, choroidal thickness, and anterior chamber depth were measured in vivo on D1, D7, D14, D22, and D28. Differences in outcome measures between eyes and groups were compared using 2-way repeated-measures ANOVA. Results: AL and myopic refraction of FD eyes increased similarly among groups during form-deprivation. FD eyes of animals raised under SL-4000 (D22: P < 0.001 and D28: P < 0.001) and SL-6500 (D22: P = 0.006 and D28: P < 0.001) recovered faster from axial elongation compared with animals raised under FL-4000. The refractive status of FD eyes reared under SL-6500, not under FL-4000 or SL-4000, was similar to control eyes on D28 (P > 0.05). However, SL-4000 and SL-6500 exhibited similar refraction on D28 than FL-4000 (P > 0.05). Choroidal thickness was significantly greater in FD eyes of chickens raised under SL-6500 than in animals raised under FL-4000 (P = 0.03). Conclusions: Compared to fluorescent light, moderate intensities of full-spectrum Sunlike LEDs can accelerate recovery from form-deprivation myopia in chickens, potentially through a change in the choroid-mediated pathway.
Databáze:	MEDLINE
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