Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study.

Autor:	Chang TC; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Celestin L; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Hodapp EA; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Grajewski AL; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Junk A; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Rothman AL; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Duerr ERH; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Swaminathan SS; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Gedde SJ; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Young TL; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI., Wiggs J; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School.; Ocular Genomics Institute, Harvard Medical School, Boston, MA., Olivier MMG; Rosalind Franklin University of Medicine and Science/The Chicago Medical School, North Chicago, IL., Quintanilla R; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Arrieta E; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Savatovsky EJ; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Vanner EA; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL., Parrish RK; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Jazyk:	angličtina
Zdroj:	Journal of glaucoma [J Glaucoma] 2022 Jul 01; Vol. 31 (7), pp. 584-589. Date of Electronic Publication: 2022 Feb 08.
DOI:	10.1097/IJG.0000000000001996
Abstrakt:	Prcis: Glaucoma cascade screening in first-degree relatives (FDRs) of young Haitian glaucoma patients had high yield for diagnosing manifest and suspected glaucoma in 30.8% of those screened despite modest participation. Purpose: To evaluate the outcomes of glaucoma cascade screening in FDRs (parents, siblings, and offspring) of Haitian juvenile open-angle glaucoma (JOAG) patients. Patients and Methods: Consecutive index patients (Haitians with JOAG) were identified, and the number/type of FDRs residing in South Florida were recorded. These FDRs were invited for free glaucoma screening, which included a comprehensive ophthalmic exam, gonioscopy, automated visual field testing and optical coherence tomographic analysis of the retinal nerve fiber layers. FDR characteristics and clinical findings from screening are reported. Results: A total of 77 FDRs were invited, 26 (33.8%) agreed to undergo screening (18 females, 9 males), which revealed 2 (7.7%) with manifest glaucoma (mean age 77.5 y; one of whom was previously unaware of his glaucoma diagnosis), 6 (23.1%) with suspected glaucoma (mean age 29.8±18.3 y), and 18 (69.2%) without manifest or suspected glaucoma (mean age 37.2±21.8 y). Siblings of index patients were least likely to participate in cascade glaucoma screening when compared with index patients' parents or offspring. FDR eyes with manifest glaucoma had significantly worse best-corrected visual acuities, higher intraocular pressures, thinner central corneal thicknesses, and thinner circumferential papillary retinal nerve fiber layer thicknesses than those without glaucoma. Conclusion: Glaucoma cascade screening of Haitian JOAG patients' FDRs revealed that 30.8% had suspected or manifest glaucoma. Future efforts centered on provider-initiated recruitment and improving public glaucoma awareness and education may increase screening participation. Competing Interests: Disclosure: The authors declare no conflict of interest. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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