Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty.

Autor:	Passos LSA; Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Becker-Greene D; Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Braulio R; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Le TD; Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Gelape CL; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., de Almeida LFR; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Rocha DPA; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Gomes CAP; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Esteves WAM; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Passaglia LG; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Dal-Bianco JP; Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Levine RA; Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Aikawa M; Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Department of Human Pathology, Sechenov First Moscow State Medical University, Moscow, Russia., Hung J; Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Dutra WO; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Belo Horizonte, Brazil., Nunes MCP; School of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil., Aikawa E; Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Department of Human Pathology, Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Jan 20; Vol. 8, pp. 804111. Date of Electronic Publication: 2022 Jan 20 (Print Publication: 2021).
DOI:	10.3389/fcvm.2021.804111
Abstrakt:	Mitral regurgitation (MR) is a major complication of the percutaneous mitral valvuloplasty (PMV). Despite high technical expertise and cumulative experience with the procedure, the incidence rate of severe MR has not decreased. Although some of MR can be anticipated by echocardiographic analysis; leaflet tearing, which leads to the most dreaded type of MR, remains unpredictable. Irregular valvular collagen remodeling is likely to compromise tissue architecture and increase the tearing risk during PMV balloon inflation. In this study, we evaluated histological and molecular characteristics of excised mitral valves from patients with rheumatic mitral stenosis (MS) who underwent emergency surgery after PMV due to severe MR caused by leaflet tear. Those findings were compared with patients who underwent elective mitral valve replacement surgery owing to severe MS, in whom PMV was not indicated. In vitro assay using peripheral blood mononuclear cells was performed to better understand the impact of the cellular and molecular alterations identified in leaflet tear mitral valve specimens. Our analysis showed that focal infiltration of inflammatory cells contributes to accumulation of MMP-1 and IFN-γ in valve leaflets. Moreover, we showed that IFN-γ increase the expression of MMP-1 in CD14 + cells (monocytes) in vitro . Thus, inflammatory cells contribute to unevenly remodel collagen resulting in variable thickening causing abnormalities in leaflet architecture making them more susceptible to laceration. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Passos, Becker-Greene, Braulio, Le, Gelape, de Almeida, Rocha, Gomes, Esteves, Passaglia, Dal-Bianco, Levine, Aikawa, Hung, Dutra, Nunes and Aikawa.)
Databáze:	MEDLINE
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