Association between zinc and body composition: An integrative review.

Autor: Cunha TA; Health Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal/RN, Brazil. Electronic address: thais.alves.018@ufrn.edu.br., Vermeulen-Serpa KM; Health Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal/RN, Brazil. Electronic address: karina.vermeulen.088@ufrn.edu.br., Grilo EC; Health Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal/RN, Brazil. Electronic address: evellyn.camara.090@ufrn.edu.br., Leite-Lais L; Department of Nutrition, Federal University of Rio Grande do Norte, Natal/RN, Brazil. Electronic address: lucia.leite@ufrn.br., Brandão-Neto J; Health Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal/RN, Brazil; Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal/RN, Brazil. Electronic address: brandao-neto@live.com., Vale SHL; Health Sciences Postgraduate Program, Federal University of Rio Grande do Norte, Natal/RN, Brazil; Department of Nutrition, Federal University of Rio Grande do Norte, Natal/RN, Brazil; Nutrition Postgraduate Program, Federal University of Rio Grande do Norte, Natal/RN, Brazil. Electronic address: sancha.vale@ufrn.br.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2022 May; Vol. 71, pp. 126940. Date of Electronic Publication: 2022 Jan 29.
DOI: 10.1016/j.jtemb.2022.126940
Abstrakt: Background: Zinc deficiency is related to lean body mass reduction, fat deposition, and obesity. Zinc acts in catalytic, structural, and regulatory functions, being an essential micronutrient to humans. It is crucial for maintaining lean body mass, synthesizing nucleic acids and proteins, and forming new tissues. Pre-existing zinc deficiency may contribute to obesity due to its relationship with fat deposition associated with short stature. This integrative review aims to analyze the association between zinc and body composition, hitherto very poorly established in previous studies.
Material and Methods: The electronic databases utilized in this review were PubMed and Web of Science. We identified titles and abstracts from 1178 articles relating to zinc and body composition that were published in the last ten years. After duplicates were removed, the reference lists of relevant reviews were checked, and 47 articles were obtained by manual search.
Main Findings and Conclusions: The articles were transversal or longitudinal studies, clinical trials, randomized controlled trials, reviews, systematic reviews, and meta-analysis. Although there was heterogeneity among the methodologies, the existence of an association between zinc and body composition was predominant among the studies. All articles concluded that zinc had positive effects on proteogenesis. Moreover, zinc metabolism is dysregulated in obese individuals, whose mechanisms remain controversial.
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Databáze: MEDLINE
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