Contemporary Non-hormonal Therapies for the Management of Vasomotor Symptoms Associated with Menopause: A Literature Review.
| Autor: | Sahni S; Division of General Internal Medicine, Jacoby Center for Breast Health, Mayo Clinic, Jacksonville, FL, USA., Lobo-Romero A; Division of General Internal Medicine, Women's Health, Mayo Clinic Rochester, MN, USA., Smith T; Division of General Internal Medicine, Women's Health, Mayo Clinic, Jacksonville, FL, USA. |
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| Jazyk: | angličtina |
| Zdroj: | TouchREVIEWS in endocrinology [touchREV Endocrinol] 2021 Nov; Vol. 17 (2), pp. 133-137. Date of Electronic Publication: 2021 Oct 13. |
| DOI: | 10.17925/EE.2021.17.2.133 |
| Abstrakt: | Nearly 75% of all menopausal women experience bothersome vasomotor symptoms including hot flushes and night sweats. Yet vasomotor symptoms continue to be an undertreated and underdiagnosed symptom of menopause which can negatively affect a woman's overall quality of life. While hormone therapy has been widely utilized to ameliorate hot flushes, not all women are candidates for use, especially those with increased risk of cardiovascular disease, thromboembolic disease, and/or women at an increased risk of certain hormone-dependent cancers. The current literature provides strong evidence for non-hormonal therapies in women who experience vasomotor symptoms. This article reviews the evidence for the use of non-hormonal pharmacologic therapies for the treatment of menopausal symptoms including antidepressants, gabapentinoids, clonidine and anticholinergics. We also review data on emerging therapies including the latest evidence on neurokinin-1 and -3 antagonists. These therapies should be considered when hormonal options are contraindicated and/or not preferred by the patient. While there are many options available, clinicians should individualize therapy based on the patient's needs and goals while mitigating bothersome side effects. Competing Interests: Financial disclosure: Sabrina Sahni, Angie Lobo-Romero and Taryn Smith have no financial or non-financial relationships or activities to declare in relation to this article. (© Touch Medical Media 2021.) |
| Databáze: | MEDLINE |
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