A prospective multicentre screening study on multidrug-resistant organisms in intensive care units in the Dutch-German cross-border region, 2017 to 2018: the importance of healthcare structures.

Autor: Glasner C; Department of Medical Microbiology and Infection Control, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Berends MS; Department of Medical Microbiology and Infection Control, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Certe Medical Diagnostics and Advice Foundation, Groningen, the Netherlands., Becker K; Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.; Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany., Esser J; Practice of Laboratory Medicine and University Osnabrück, Department of Dermatology, Environmental Medicine and Health Theory, Osnabrück, Germany., Gieffers J; Institute for Microbiology, Hygiene and Laboratory Medicine, Klinikum Lippe, Detmold, Germany., Jurke A; North Rhine-Westphalian Centre for Health, Section Infectious Disease Epidemiology, Bochum, Germany., Kampinga G; Department of Medical Microbiology and Infection Control, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Kampmeier S; Institute of Hygiene, University Hospital Münster, Münster, Germany., Klont R; Laboratory Microbiology Twente Achterhoek, Hengelo, the Netherlands., Köck R; Institute of Hygiene, DRK Kliniken Berlin, Berlin, Germany.; Institute of Hygiene, University Hospital Münster, Münster, Germany., von Müller L; Institute for Laboratory Medicine, Microbiology and Hygiene, Christophorus-Kliniken GmbH, Coesfeld, Germany., Al Naemi N; Laboratory Microbiology Twente Achterhoek, Hengelo, the Netherlands., Ott A; Certe Medical Diagnostics and Advice Foundation, Groningen, the Netherlands., Ruijs G; Laboratory for Medical Microbiology and Infectious Diseases, Isala, Zwolle, the Netherlands., Saris K; Department of Medical Microbiology, Radboud University Medical Centre and Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands., Tami A; Department of Medical Microbiology and Infection Control, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Voss A; Department of Medical Microbiology, Radboud University Medical Centre and Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands., Waar K; Izore, Centre for Infectious Diseases Friesland, Leeuwarden, the Netherlands.; Certe Medical Diagnostics and Advice Foundation, Groningen, the Netherlands., van Zeijl J; Izore, Centre for Infectious Diseases Friesland, Leeuwarden, the Netherlands.; Certe Medical Diagnostics and Advice Foundation, Groningen, the Netherlands., Friedrich AW; Department of Medical Microbiology and Infection Control, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; European Prevention Networks in Infection Control, University Hospital Münster, Münster, Germany.
Jazyk: angličtina
Zdroj: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2022 Feb; Vol. 27 (5).
DOI: 10.2807/1560-7917.ES.2022.27.5.2001660
Abstrakt: BackgroundAntimicrobial resistance poses a risk for healthcare, both in the community and hospitals. The spread of multidrug-resistant organisms (MDROs) occurs mostly on a local and regional level, following movement of patients, but also occurs across national borders.AimThe aim of this observational study was to determine the prevalence of MDROs in a European cross-border region to understand differences and improve infection prevention based on real-time routine data and workflows.MethodsBetween September 2017 and June 2018, 23 hospitals in the Dutch (NL)-German (DE) cross-border region (BR) participated in the study. During 8 consecutive weeks, patients were screened upon admission to intensive care units (ICUs) for nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA) and rectal carriage of vancomycin-resistant Enterococcus faecium / E. faecalis (VRE), third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE) and carbapenem-resistant Enterobacteriaceae (CRE). All samples were processed in the associated laboratories.ResultsA total of 3,365 patients were screened (median age: 68 years (IQR: 57-77); male/female ratio: 59.7/40.3; NL-BR: n = 1,202; DE-BR: n = 2,163). Median screening compliance was 60.4% (NL-BR: 56.9%; DE-BR: 62.9%). MDRO prevalence was higher in DE-BR than in NL-BR, namely 1.7% vs 0.6% for MRSA (p = 0.006), 2.7% vs 0.1% for VRE (p < 0.001) and 6.6% vs 3.6% for 3GCRE (p < 0.001), whereas CRE prevalence was comparable (0.2% in DE-BR vs 0.0% in NL-BR ICUs).ConclusionsThis first prospective multicentre screening study in a European cross-border region shows high heterogenicity in MDRO carriage prevalence in NL-BR and DE-BR ICUs. This indicates that the prevalence is probably influenced by the different healthcare structures.
Databáze: MEDLINE