Circulating trimethylamine N-oxide levels following fish or seafood consumption.

Autor: Wang Z; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code NC10, Cleveland, OH, 44195, USA., Tang WHW; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code NC10, Cleveland, OH, 44195, USA.; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA., O'Connell T; LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, 27616, USA.; Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Garcia E; LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, 27616, USA.; Laboratory Corporation of America Holdings (Labcorp), Morrisville, NC, 27560, USA., Jeyarajah EJ; LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, 27616, USA., Li XS; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code NC10, Cleveland, OH, 44195, USA., Jia X; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code NC10, Cleveland, OH, 44195, USA., Weeks TL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code NC10, Cleveland, OH, 44195, USA., Hazen SL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code NC10, Cleveland, OH, 44195, USA. hazens@ccf.org.; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. hazens@ccf.org.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2022 Aug; Vol. 61 (5), pp. 2357-2364. Date of Electronic Publication: 2022 Feb 03.
DOI: 10.1007/s00394-022-02803-4
Abstrakt: Purpose: Some species of fish and seafood are high in trimethylamine N-oxide (TMAO), which accumulates in muscle where it protects against pressure and cold. Trimethylamine (TMA), the metabolic precursor to TMAO, is formed in fish during bacterial spoilage. Fish intake is promoted for its potential cardioprotective effects. However, numerous studies show TMAO has pro-atherothrombotic properties. Here, we determined the effects of fish or seafood consumption on circulating TMAO levels in participants with normal renal function.
Methods: TMAO and omega-3 fatty acid content were quantified across multiple different fish or seafood species by mass spectrometry. Healthy volunteers (n = 50) were recruited for three studies. Participants in the first study consented to 5 consecutive weekly blood draws and provided dietary recall for the 24 h preceding each draw. In the second study, TMAO levels were determined following defined low and high TMAO diets. Finally, participants consumed test meals containing shrimp, tuna, fish sticks, salmon or cod. TMAO levels were quantified by mass spectrometry in blood collected before and after dietary challenge.
Results: TMAO + TMA content varied widely across fish and seafood species. Consumption of fish sticks, cod, and to a lesser extent salmon led to significant increases in circulating TMAO levels. Within 1 day, circulating TMAO concentrations in all participants returned to baseline levels.
Conclusions: We conclude that some fish and seafood contain high levels of TMAO, and may induce a transient elevation in TMAO levels in some individuals. Selection of low TMAO content fish is prudent for subjects with elevated TMAO, cardiovascular disease or impaired renal function.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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