Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts.
| Autor: | Bisserier M; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Saffran N; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Brojakowska A; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Sebastian A; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States., Evans AC; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.; Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States., Coleman MA; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.; Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States., Walsh K; School of Medicine, University of Virginia, Charlottesville, VA, United States., Mills PJ; Center of Excellence for Research and Training in Integrative Health, University of California, San Diego, San Diego, CA, United States., Garikipati VNS; Department of Emergency Medicine, Dorothy M. Davis Heart Lung and Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, United States., Arakelyan A; Bioinformatics Group, The Institute of Molecular Biology, The National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia., Hadri L; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Goukassian DA; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in genetics [Front Genet] 2022 Jan 17; Vol. 12, pp. 812188. Date of Electronic Publication: 2022 Jan 17 (Print Publication: 2021). |
| DOI: | 10.3389/fgene.2021.812188 |
| Abstrakt: | During spaceflight, astronauts are exposed to multiple unique environmental factors, particularly microgravity and ionizing radiation, that can cause a range of harmful health consequences. Over the past decades, increasing evidence demonstrates that the space environment can induce changes in gene expression and RNA processing. Long non-coding RNA (lncRNA) represent an emerging area of focus in molecular biology as they modulate chromatin structure and function, the transcription of neighboring genes, and affect RNA splicing, stability, and translation. They have been implicated in cancer development and associated with diverse cardiovascular conditions and associated risk factors. However, their role on astronauts' health after spaceflight remains poorly understood. In this perspective article, we provide new insights into the potential role of exosomal lncRNA after spaceflight. We analyzed the transcriptional profile of exosomes isolated from peripheral blood plasma of three astronauts who flew on various Shuttle missions between 1998-2001 by RNA-sequencing. Computational analysis of the transcriptome of these exosomes identified 27 differentially expressed lncRNAs with a Log Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Bisserier, Saffran, Brojakowska, Sebastian, Evans, Coleman, Walsh, Mills, Garikipati, Arakelyan, Hadri and Goukassian.) |
| Databáze: | MEDLINE |
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