Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier.

Autor: Widjaja G; Postgraduate Study, Universitas Krisnadwipayana, Bekasi, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia., Jalil AT; Faculty of Biology and Ecology, Yanka Kupala State University of Grodno, 230023 Grodno, Belarus; College of Technical Engineering, The Islamic University, Najaf, Iraq; Department of Dentistry, Kut University College, Kut, Wasit 52001, Iraq., Budi HS; Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya 60132, Indonesia. Electronic address: hendrik-s-b@fkg.unair.ac.id., Abdelbasset WK; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt., Efendi S; Fasilkom-TI, Universitas Sumatera Utara, Medan, Indonesia. Electronic address: syahril1@usu.ac.id., Suksatan W; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok 10210, Thailand., Rita RS; Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Indonesia., Satria AP; Faculty of Nursing, Universitas Muhammadiyah Kalimantan Timur, Samarinda 75124, Indonesia., Aravindhan S; Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India., Saleh MM; Department of Biophysics, College of Applied Sciences, University Of Anbar, Iraq., Shalaby MN; Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Egypt., Yumashev AV; Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2022 Apr; Vol. 105, pp. 108537. Date of Electronic Publication: 2022 Jan 29.
DOI: 10.1016/j.intimp.2022.108537
Abstrakt: Today, the application of mesenchymal stromal/stem cells (MSCs) and their exosomes to treat degenerative diseases has received attention. Due to the characteristics of these cells, such as self-renewability, differentiative and immunomodulatory effects, their use in laboratory and clinical studies shows promising results. However, the allogeneic transplantation problems of MSCs limit the use of these cells in the clinic. Scientists propose the application of exosomes to use from the therapeutic effect of MSCs and overcome their defects. These vesicles change the target cell behaviour and transcription profile by transferring various cargo such as proteins, mi-RNAs, and lipids. One of the degenerative tissue diseases in which MSCs and their exosomes are used in their treatment is intervertebral disc disease (IDD). Different factors such as genetics, nutrition, ageing, and environmental factors play a significant role in the onset and progression of this disease. These factors affect the cellular and molecular properties of the disc, leading to tissue destruction. Nucleus pulposus cells (NPCs) are among the most important cells involved in the pathogenesis of disc degeneration. MSCs exert their therapeutic effects by differentiating, reducing apoptosis, increasing proliferation, and decreasing senescence in NPCs. In addition, the use of MSCs and their exosomes also affects the annulus fibrosus and cartilaginous endplate cells in disc tissue and prevents disc degeneration progression.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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