Changes in serum neurofilament light chain levels following narrowband ultraviolet B phototherapy in clinically isolated syndrome.

Autor: Fabis-Pedrini MJ; Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Australia., Kuhle J; Neurology Clinic and Policlinic, MS Centre and Research Centre for Clinical Neuroimmunology and Neuroscience Basel, University of Basel, Basel, Switzerland., Roberts KMA; Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia., Trend S; Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.; Telethon Kids Institute, University of Western Australia, Perth, Australia., Jones AP; Telethon Kids Institute, University of Western Australia, Perth, Australia., Maceski A; Neurology Clinic and Policlinic, MS Centre and Research Centre for Clinical Neuroimmunology and Neuroscience Basel, University of Basel, Basel, Switzerland., Carroll WM; Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia., Lucas RM; National Centre for Epidemiology & Population Health, Research School of Population Health, Australian National University, Canberra, Australia.; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia., Mastaglia FL; Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Australia., Hart PH; Telethon Kids Institute, University of Western Australia, Perth, Australia., Kermode AG; Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Australia.; Institute for Immunology and Infectious Disease, Murdoch University, Perth, Australia.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2022 Feb; Vol. 12 (2), pp. e2494. Date of Electronic Publication: 2022 Jan 27.
DOI: 10.1002/brb3.2494
Abstrakt: Objective: To determine whether serum neurofilament light chain (sNfL) levels are suppressed in patients with the clinically isolated syndrome (CIS) following narrowband ultraviolet B phototherapy (UVB-PT).
Methods: sNfL levels were measured using a sensitive single-molecule array assay at baseline and up to 12 months in 17 patients with CIS, 10 of whom received UVB-PT, and were compared with healthy control (HC) and early relapsing remitting multiple sclerosis (RRMS) group. sNfL levels were correlated with magnetic resonance imaging total lesion volume (LV) determined using icobrain version 4.4.1 and with clinical outcomes.
Results: Baseline median sNfL levels were significantly higher in the CIS (20.6 pg/mL, interquartile range [IQR] 13.7-161.4) and RRMS groups (36.6 pg/ml [IQR] 16.2-212.2) than in HC (10.7 pg/ml [IQR] 4.9-21.5) (p = .012 and p = .0002, respectively), and were strongly correlated with T2 and T1 LV at 12 months (r = .800; p = .014 and r = .833; p = .008, respectively) in the CIS group. Analysis of changes in sNfL levels over time in the CIS group showed a significant cumulative suppressive effect of UVB-PT in the first 3 months (UVB-PT -10.6% vs non-UVB-PT +58.3%; p = .04) following which the levels in the two groups converged and continued to fall.
Conclusions: Our findings provide the basis for further studies to determine the utility of sNfL levels as a marker of neuro-axonal damage in CIS and early MS and for assessing the efficacy of new therapeutic interventions such as UVB-PT.
(© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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