Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort.

Autor:	Hirano I; Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Collins MH; Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., King E; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Sun Q; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Chehade M; Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Abonia JP; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Allergy and Immunology, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Bonis PA; Division of Gastroenterology, Tufts Medical Center, Boston, Massachusetts, USA., Capocelli KE; Digestive Health Institute, Children's Hospital of Colorado, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO, USA., Dellon ES; University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Falk GW; Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Gonsalves N; Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Gupta SK; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Riley Hospital for Children/Indiana University School of Medicine, and Community Health Network, Indianapolis, IN, USA., Leung J; Division of Gastroenterology, Tufts Medical Center, Boston, Massachusetts, USA., Katzka D; Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA., Menard-Katcher P; Division of Gastroenterology, University of Colorado, Denver, Colorado, USA., Khoury P; Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland, USA., Klion A; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Mukkada VA; Department of Gastroenterology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA., Peterson K; Department of Gastroenterology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA., Shoda T; Division of Allergy and Immunology, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Rudman-Spergel AK; Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Spergel JA; Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine of University of Pennsylvania, Philadelphia, PA, USA., Yang GY; Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Rothenberg ME; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Allergy and Immunology, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Aceves SS; Department of Pediatrics and Medicine, University of California San Diego, San Diego, California, USA., Furuta GT; Digestive Health Institute, Children's Hospital of Colorado, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO, USA.
Jazyk:	angličtina
Zdroj:	The American journal of gastroenterology [Am J Gastroenterol] 2022 Mar 01; Vol. 117 (3), pp. 413-423.
DOI:	10.14309/ajg.0000000000001625
Abstrakt:	Introduction: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations. Methods: Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features. Results: Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002). Discussion: Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies. (Copyright © 2022 by The American College of Gastroenterology.)
Databáze:	MEDLINE
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