Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.

Autor:	Hunter KE; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia kylie.hunter@sydney.edu.au., Johnson BJ; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia., Askie L; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Golley RK; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia., Baur LA; Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia., Marschner IC; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Taylor RW; Department of Medicine, University of Otago, Dunedin, New Zealand., Wolfenden L; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia., Wood CT; School of Medicine, Duke University, Durham, North Carolina, USA., Mihrshahi S; Department of Health Systems and Populations, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Hayes AJ; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Rissel C; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Robledo KP; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., O'Connor DA; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.; Monash Department of Clinical Epidemiology, Cabrini Institute, Malvern, Victoria, Australia., Espinoza D; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Staub LP; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Chadwick P; Centre For Behaviour Change, University College London, London, UK., Taki S; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Population Health Research and Evaluation Hub, Sydney Local Health District, Camperdown, New South Wales, Australia., Barba A; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Libesman S; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Aberoumand M; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia., Smith WA; Canterbury Community Health Centre, Sydney Local Health District, Campsie, New South Wales, Australia.; Consumer Representative, Sydney, New South Wales, Australia., Sue-See M; Consumer Representative, Sydney, New South Wales, Australia., Hesketh KD; Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia., Thomson JL; Agricultural Research Service, USDA, Stoneville, Mississippi, USA., Bryant M; Department of Health Sciences and the Hull York Medical School, University of York, York, UK., Paul IM; Penn State College of Medicine, Hershey, Pennsylvania, USA., Verbestel V; Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium., Stough CO; Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA., Wen LM; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Population Health Research and Evaluation Hub, Sydney Local Health District, Camperdown, New South Wales, Australia., Larsen JK; Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands., O'Reilly SL; School of Agriculture and Food Science, University College Dublin, Dublin, Ireland., Wasser HM; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Savage JS; Department of Nutritional Sciences & Center for Childhood Obesity Research, Pennsylvania State University, University Park, Pennsylvania, USA., Ong KK; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Salvy SJ; Research Center for Health Equity, Cedars-Sinai Medical Center, West Hollywood, California, USA., Messito MJ; Grossman School of Medicine, New York University, New York, New York, USA., Gross RS; Grossman School of Medicine, New York University, New York, New York, USA., Karssen LT; Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands., Rasmussen FE; Department of Global Public Health, Karolinska Institute, Stockholm, Sweden., Campbell K; Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia., Linares AM; College of Nursing, University of Kentucky, Lexington, Kentucky, USA., Øverby NC; Faculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway., Palacios C; Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida, USA., Joshipura KJ; Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.; Center for Clinical Research and Health Promotion, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA., González Acero C; Social Protection and Health Division, Inter-American Development Bank, Santo Domingo, Distrito Nacional, Dominican Republic., Lakshman R; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Thompson AL; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Anthropology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Maffeis C; Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy., Oken E; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA., Ghaderi A; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden., Campos Rivera M; Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, USA., Pérez-Expósito AB; Social Protection and Health Division, Inter-American Development Bank, Washington, District of Columbia, USA., Banna JC; Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, Hawaii, USA., de la Haye K; Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA., Goran M; Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA., Røed M; Faculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway., Anzman-Frasca S; Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA., Taylor BJ; Better Start National Science Challenge, University of Otago, Dunedin, New Zealand., Seidler AL; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Jan 20; Vol. 12 (1), pp. e048166. Date of Electronic Publication: 2022 Jan 20.
DOI:	10.1136/bmjopen-2020-048166
Abstrakt:	Introduction: Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. Methods and Analysis: Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. Ethics and Dissemination: Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. Prospero Registration Number: CRD42020177408. Competing Interests: Competing interests: AB, ALS, BJJ, KEH, MA, RKG, SL and LPS reports grants from NHMRC Ideas Grant TOPCHILD (Transforming Obesity Prevention for CHILDren) (GNT1186363); APE and CGA reports grants administered by the Inter-American Development Bank from The Government of Japan and The PepsiCo Foundation; ALT reports grants from National Institute of Health; BJT reports grants from NZ Health Research Council; EO reports grants from the US National Institutes of Health, and the Canadian Institutes for Health Research; IMP reports grants from NIH/NIDDK; JSS reports grants from PCORI, NIH NIDDK and NHLBI, and personal fees from Danone Organic, American Academy of Pediatrics, and Lets Move Maine; LTK and JKL reports grants from Fonds NutsOhra; MCR reports grants from National Institute on Minority Health and Health Disparities-National Institutes of Health/Center for Collaborative Research in Health Disparities, and personal fees from Rhythm Pharmaceuticals; RSG reports grants from US Department of Agriculture and NIH/NICHD. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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