Photobiomodulation of gingival lesions resulting from autoimmune diseases: systematic review and meta-analysis.

Autor: de Carvalho MM; School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, 37130-001, Brazil., Hidalgo MAR; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara, FOAr/UNESP), UNESP - São Paulo State University, Araraquara, SP, Brazil., Scarel-Caminaga RM; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara, FOAr/UNESP), UNESP - São Paulo State University, Araraquara, SP, Brazil., Ribeiro Junior NV; School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, 37130-001, Brazil., Sperandio FF; Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, MG, Brazil.; Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada., Pigossi SC; School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, 37130-001, Brazil., de Carli ML; School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, 37130-001, Brazil. marina.carli@unifal-mg.edu.br.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2022 May; Vol. 26 (5), pp. 3949-3964. Date of Electronic Publication: 2022 Jan 13.
DOI: 10.1007/s00784-021-04362-0
Abstrakt: Objectives: To evaluate the effects of photobiomodulation (PBM) in gingival lesions resulting from autoimmune diseases; to compare PBM and topical corticosteroid (CS) treatment; and to assess PBM outcome over time of follow-up.
Materials and Methods: A comprehensive electronic search was performed in four electronic databases. Treatment effects were measured through visual analog scale of pain (VAS) and clinical evolution of lesion (Thongprasom scale for oral lichen planus (OLP)). Meta-analysis was performed to compare PBM with topical corticosteroid treatment and to evaluate PBM effect over time of follow-up.
Results: Seventeen studies were included in this review, of which six were used for the meta-analysis. Meta-analysis results showed no significant differences between PBM and topical CS in pain reduction at baseline (MD = 0.20, 95% CI =  - 0.92, 1.32, p = 0.72) and 60-day follow-up (MD = 0.63, 95% CI =  - 3.93, 5.19, p = 0.79); however, VAS showed significant pain reduction when compared before and after PBM at 30-day (MD =  - 3.52, 95% CI =  - 5.40, - 1.64, p = 0.0002) and 60-day (MD =  - 5.04, 95% CI =  - 5.86, - 4.22, p < 0.00001) follow-up. Thongprasom clinical scale for OLP also showed significant improvement at 30-day follow-up (MD =  - 2.50, 95% CI =  - 2.92, - 2.08, p < 0.00001) after PBM.
Conclusion: PBM led to significant reduction of pain and clinical scores of the lesions, not having shown significant differences when compared to topical CS.
Clinical Relevance: PBM has been used in the treatment of autoimmune gingival lesions, but so far there is little strong evidence to support its use.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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