Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial.

Autor: Radosevic A; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain. aradosevic@psmar.cat., Quesada R; Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Serlavos C; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Sánchez J; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Zugazaga A; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Sierra A; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Coll S; Hepatology Section, Gastroenterology Department, Hospital del Mar. IMIM, Barcelona, Spain., Busto M; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Aguilar G; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Flores D; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Arce J; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Maiques JM; Department of Radiology, Hospital del Mar de Barcelona, Passeig Maritim 25-29, 08003, Barcelona, Spain., Garcia-Retortillo M; Hepatology Section, Gastroenterology Department, Hospital del Mar. IMIM, Barcelona, Spain., Carrion JA; Hepatology Section, Gastroenterology Department, Hospital del Mar. IMIM, Barcelona, Spain., Visa L; Department of Oncology-IMIM-Ciberonc, Hospital del Mar, Barcelona, Spain., Villamonte M; Department of Surgery, Hospital del Mar, Barcelona, Spain., Pueyo E; Department of Surgery, Hospital del Mar, Barcelona, Spain., Berjano E; BioMIT, Department of Electronic Engineering, Universitat Politècnica de València, Valencia, Spain., Trujillo M; BioMIT, Department of Applied Mathematics, Universitat Politècnica de València, Valencia, Spain., Sánchez-Velázquez P; Department of Surgery, Hospital del Mar, Barcelona, Spain., Grande L; Department of Surgery, Hospital del Mar, Barcelona, Spain., Burdio F; Department of Surgery, Hospital del Mar, Barcelona, Spain.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jan 10; Vol. 12 (1), pp. 316. Date of Electronic Publication: 2022 Jan 10.
DOI: 10.1038/s41598-021-03802-x
Abstrakt: Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA as well as morphology of corresponding ablation zones. HCC and MT patients with 1.5-4 cm tumors, suitable for ablation, were randomized into MWA or RFA Groups. The primary endpoint was short-to-long diameter ratio of ablation zone (SLR). Primary technical success (TS) and a cumulative local tumor progression (LTP) after a median 2-year follow-up were compared. Between June 2015 and April 2020, 82 patients were randomly assigned (41 patients per group). For the per-protocol analysis, five patients were excluded. MWA created larger ablation zones than RFA (p = 0.036) although without differences in SLR (0.5 for both groups, p = 0.229). The TS was achieved in 98% (46/47) and 90% (45/50) (p = 0.108), and LTP was observed in 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66-5.3], p = 0.238) of tumors in MWA vs. RFA Group, respectively. Major complications were found in 5 cases (11%) vs. 2 cases (4%), without statistical significance. MWA and RFA show similar SLR, effectiveness and safety in liver tumors between 1.5 and 4 cm.
(© 2022. The Author(s).)
Databáze: MEDLINE
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