| Autor: |
Guseva GB; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences (ISC RAS), 153045 Ivanovo, Russian Federation., Antina EV; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences (ISC RAS), 153045 Ivanovo, Russian Federation., Berezin MB; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences (ISC RAS), 153045 Ivanovo, Russian Federation., Pavelyev RS; Kazan Federal University, 420008 Kazan, Russian Federation., Kayumov AR; Kazan Federal University, 420008 Kazan, Russian Federation., Ostolopovskaya OV; Kazan Federal University, 420008 Kazan, Russian Federation., Gilfanov IR; Kazan State Medical University, 420012 Kazan, Russian Federation., Frolova LL; Institute of Chemistry, Federal Research Center 'Komi Scientific Centre', 167000 Syktyvkar, Russian Federation., Kutchin AV; Institute of Chemistry, Federal Research Center 'Komi Scientific Centre', 167000 Syktyvkar, Russian Federation., Akhverdiev RF; Kazan Federal University, 420008 Kazan, Russian Federation., Lisovskaya SA; Kazan State Medical University, Scientific Research Institute of Epidemiology and Microbiology, 420012 Kazan, Russian Federation., Trizna EY; Kazan Federal University, 420008 Kazan, Russian Federation., Lodochnikova OA; Kazan Federal University, 420008 Kazan, Russian Federation.; Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, 420008 Kazan, Russian Federation., Islamov DR; Kazan Federal University, 420008 Kazan, Russian Federation.; Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, 420008 Kazan, Russian Federation., Efimov SV; Kazan Federal University, 420008 Kazan, Russian Federation., Klochkov VV; Kazan Federal University, 420008 Kazan, Russian Federation., Khodov IA; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences (ISC RAS), 153045 Ivanovo, Russian Federation.; Kazan Federal University, 420008 Kazan, Russian Federation., Boichuk SV; Kazan State Medical University, 420012 Kazan, Russian Federation., Nikitina LE; Kazan Federal University, 420008 Kazan, Russian Federation.; Kazan State Medical University, 420012 Kazan, Russian Federation. |
| Abstrakt: |
This article describes the design and biological properties of a BODIPY FL-labeled monoterpenoid BF 2 - meso -(4-((1″ R )-6″,6″-dimethylbicyclo[3.1.1]hept-2″-ene-2″)yl-methoxycarbonylpropyl)-3,3',5,5'-tetramethyl-2,2'-dipyrromethene conjugate (BODIPYmyrt). The fluorophore was characterized using X-ray, NMR, MS, and UV/vis spectroscopy. The conjugate exhibits a high quantum yield (to ∼100%) in the region 515-518 nm. BODIPYmyrt effectively penetrates the membranes of the bacterial and fungal cells and therefore can be used to examine the features of a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi as well. Moreover, BODIPYmyrt exhibits a moderate tropism to the subcellular structures in mammalian cells (e.g., mitochondria), thereby providing an attractive scaffold for fluorophores to examine these particular organelles. |
