The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect.

Autor:	Bestea L; Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France., Paoli M; Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France., Arrufat P; Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France., Ronsin B; Centre for Integrative Biology, Université de Toulouse, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France., Carcaud J; Evolution, Genomes, Behavior and Ecology, CNRS (UMR 9191), IRD, University Paris Saclay, 1 Avenue de la Terrasse, Gif-sur-Yvette 91198, France., Sandoz JC; Evolution, Genomes, Behavior and Ecology, CNRS (UMR 9191), IRD, University Paris Saclay, 1 Avenue de la Terrasse, Gif-sur-Yvette 91198, France., Velarde R; Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France.; Latin American Society for Bee Research (SOLATINA), Bolivian Chapter, Santivañez 0134, Cochabamba, Bolivia., Giurfa M; Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France.; College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China.; Institut Universitaire de France (IUF), Paris, France., de Brito Sanchez MG; Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2021 Dec 11; Vol. 25 (1), pp. 103619. Date of Electronic Publication: 2021 Dec 11 (Print Publication: 2022).
DOI:	10.1016/j.isci.2021.103619
Abstrakt:	The neuropeptide F (NPF) and its short version (sNPF) mediate food- and stress-related responses in solitary insects. In the honeybee, a social insect where food collection and defensive responses are socially regulated, only sNPF has an identified receptor. Here we increased artificially sNPF levels in honeybee foragers and studied the consequences of this manipulation in various forms of appetitive and aversive responsiveness. Increasing sNPF in partially fed bees turned them into the equivalent of starved animals, enhancing both their food consumption and responsiveness to appetitive gustatory and olfactory stimuli. Neural activity in the olfactory circuits of fed animals was reduced and could be rescued by sNPF treatment to the level of starved bees. In contrast, sNPF had no effect on responsiveness to nociceptive stimuli. Our results thus identify sNPF as a key modulator of hunger and food-related responses in bees, which are at the core of their foraging activities. Competing Interests: The authors declare that they have no competing interests. (© 2021 The Authors.)
Databáze:	MEDLINE
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