Functional virus-specific memory T cells survey glioblastoma.

Autor: Ning J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Gavil NV; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Wu S; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Wijeyesinghe S; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Weyu E; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Ma J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Li M; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Grigore FN; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Dhawan S; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Skorput AGJ; The Norris Cotton Cancer Center, Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, 03756, USA., Musial SC; The Norris Cotton Cancer Center, Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, 03756, USA., Chen CC; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA., Masopust D; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA., Rosato PC; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, 55455, USA. pamela.c.rosato@dartmouth.edu.; The Norris Cotton Cancer Center, Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, 03756, USA. pamela.c.rosato@dartmouth.edu.
Jazyk: angličtina
Zdroj: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2022 Aug; Vol. 71 (8), pp. 1863-1875. Date of Electronic Publication: 2022 Jan 10.
DOI: 10.1007/s00262-021-03125-w
Abstrakt: Glioblastoma multiforme (GBM) is among the most aggressive, treatment-resistant cancers, and despite standard of care surgery, radiation and chemotherapy, is invariably fatal. GBM is marked by local and systemic immunosuppression, contributing to resistance to existing immunotherapies that have had success in other tumor types. Memory T cells specific for previous infections reside in tissues throughout the host and are capable of rapid and potent immune activation. Here, we show that virus-specific memory CD8 + T cells expressing tissue-resident markers populate the mouse and human glioblastoma microenvironment. Reactivating virus-specific memory T cells through intratumoral delivery of adjuvant-free virus-derived peptide triggered local immune activation. This delivery translated to antineoplastic effects, which improved survival in a murine glioblastoma model. Our results indicate that virus-specific memory T cells are a significant part of the glioblastoma immune microenvironment and may be leveraged to promote anti-tumoral immunity.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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