Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.

Autor:	Kristensen JH; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Bo Hasselbalch R; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Pries-Heje M; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Nielsen PB; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Dehlbæk Knudsen A; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Infectious Disease, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Fogh K; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Boesgaard Norsk J; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Eiken A; Department of Endocrinology and Copenhagen Center for Translational Research, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Andersen O; Department of Emergency and Department of Clinical Research, Copenhagen University Hospital, Amager og Hvidovre, Kettegård Alle 30, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Fischer TK; Department of Clinical Research, Copenhagen University Hospital - Nordsjællands Hospital, Dyrehavevej 29, Hillerød, Denmark.; Department of Public Health, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Juul Jensen CA; Department of Clinical Biochemistry, Copenhagen University Hospital - Nordsjællands Hospital, Dyrehavevej 29, Hillerød, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Torp-Pedersen C; Department of Clinical Research, Copenhagen University Hospital - Nordsjællands Hospital, Dyrehavevej 29, Hillerød, Denmark.; Department of Public Health, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Rungby J; Department of Endocrinology and Copenhagen Center for Translational Research, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Ditlev SB; Department of Pulmonary Medicine and Copenhagen Center for Translational Research, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Hageman I; Mental Health Services - The Capital Region of Denmark, Kristineberg 3, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Møgelvang R; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Gybel-Brask M; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Dessau RB; Department of Clinical Microbiology, Zealand University Hospital - Slagelse, Ingemannsvej 46, Slagelse, Denmark.; Institut for Regional Sundhedsforskning, University of Southern Denmark, J.B. Winsløws Vej 19, Odense, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Harritshøj L; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Folke F; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Copenhagen University Hospital - Copenhagen Emergency Medical Services, Telegrafvej 5A, Ballerup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Engel Møller ME; Department of Infectious Disease, Copenhagen University Hospital - Amager and Hvidovre, Kettegaard Alle 30, Hvidovre, Denmark., Benfield T; Department of Infectious Disease, Copenhagen University Hospital - Amager and Hvidovre, Kettegaard Alle 30, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark., Sværke Jørgensen C; Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark., Rye Ostrowski S; Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Dam Nielsen S; Department of Infectious Disease, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Bundgaard H; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark., Iversen K; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Aug 12; Vol. 226 (1), pp. 6-10.
DOI:	10.1093/infdis/jiac001
Abstrakt:	Background: The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19). Methods: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination. Results: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found. Conclusions: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19. Competing Interests: Potential conflicts of interest. H. B. received lecture fee from BMS. F. F. received research grants from the Novo Nordisk Foundation and the Laerdal Foundation. M. G.-B. reports working as an unpaid chairman for the Committee for Transfusion Medicine, Danish Society for Clinical Immunology. A. D. K. received a research grant from the Danish Heart Foundation. T. B. reports grants for his institution from the Novo Nordisk Foundation, Simonsen Foundation, Lundbeck Foundation, Kai Foundation, and Erik and Susanna Olesen’s Charitable Fund. T. B. also reports the following: an unrestricted grant for his institution and working on the advisory board for GSK; an unrestricted grant for his institution, working as a principal investigator for a clinical trial, and working on the advisory board for Pfizer; working as a principal investigator for a clinical trial for Boehringer Ingelheim; an unrestricted grant for his institution, working as a principal investigator for a clinical trial, and working on the advisory board for Gilead Sciences; an unrestricted grant for his institution, working as a principal investigator, and working on the advisory board for MSD; working as a board member for Pentabase; working as a principal investigator for clinical trials for Roche, Novartis, and Kancera AB; and working on the advisory board for Janssen and Astra Zeneca. T. B. received consulting fees from GSK and Pfizer. T. B. held lectures for GSK, Pfizer, Gilead Sciences, Boehringer Ingelheim, Abbvie, and Astra Zeneca. T. B. received a donation of trial medication from Eli Lilly. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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