The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms.

Autor:	Hollas MAR; Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Robey MT; Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Fellers RT; Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., LeDuc RD; Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Thomas PM; Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Kelleher NL; Departments of Molecular Biosciences, Chemistry, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.
Jazyk:	angličtina
Zdroj:	Nucleic acids research [Nucleic Acids Res] 2022 Jan 07; Vol. 50 (D1), pp. D526-D533.
DOI:	10.1093/nar/gkab1086
Abstrakt:	The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics' (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed by our cells and include the unique combination of post-translational modifications (PTMs), alternative splicing and other sources of variation deriving from a specific gene. The HPfA uses a FAIR system to assign persistent identifiers to proteoforms which allows for redundancy calling and tracking from prior and future studies in the growing community of proteoform biology and measurement. The HPfA is organized around open ontologies and enables flexible classification of proteoforms. To achieve this, a public registry of experimentally verified proteoforms was also created. Submission of new proteoforms can be processed through email vianrtdphelp@northwestern.edu, and future iterations of these proteoform atlases will help to organize and assign function to proteoforms, their PTMs and their complexes in the years ahead. (© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.)
Databáze:	MEDLINE
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