Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression.

Autor: Kiewa J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Meltzer-Brody S; Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA., Milgrom J; Parent-Infant Research Institute, Austin Health, Melbourne, Victoria, Australia.; Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Guintivano J; Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA., Hickie IB; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia., Whiteman DC; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Olsen CM; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Colodro-Conde L; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia., Byrne EM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Jazyk: angličtina
Zdroj: Depression and anxiety [Depress Anxiety] 2022 Mar; Vol. 39 (3), pp. 182-191. Date of Electronic Publication: 2022 Jan 05.
DOI: 10.1002/da.23232
Abstrakt: Background: Distinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD).
Methods: We conducted a genome-wide association study using PND cases (Edinburgh Postnatal Depression Scale score ≥ 13) from the Australian Genetics of Depression Study 2018 data (n = 3804) and screened controls (n = 6134). Results of gene-set enrichment analysis were compared with those of women with non-PND. For six psychiatric disorders/traits, genetic correlations with PND were evaluated, and logistic regression analysis reported polygenic score (PGS) association with both PND and NPD.
Results: Genes differentially expressed in ovarian tissue were significantly enriched (stdBeta = 0.07, p = 3.3e-04), but were not found to be associated with NPD. The genetic correlation between PND and MDD was 0.93 (SE = 0.07; p = 3.5e-38). Compared with controls, PGS for MDD are higher for PND cases (odds ratio [OR] = 1.8, confidence interval [CI] = [1.7-1.8], p = 9.5e-140) than for NPD cases (OR = 1.6, CI = [1.5-1.7], p = 1.2e-49). Highest risk is for those reporting both antenatal and postnatal depression, irrespective of prior MDD history.
Conclusions: PND has a high genetic overlap with MDD, but points of distinction focus on differential expression in ovarian tissue and higher MDD PGS, particularly for women experiencing both antenatal and postpartum PND.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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