Interactions of Extracellular Vesicles from Pathogenic Fungi with Innate Leukocytes.

Autor:	Freitas MS; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, SP, Brazil., Pessoni AM; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, SP, Brazil., Coelho C; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK., Bonato VLD; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, SP, Brazil., Rodrigues ML; Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil.; Instituto de Microbiologia Paulo de Góes (UFRJ), Rio de Janeiro, Brazil., Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Almeida F; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, SP, Brazil. fbralmeida@usp.br.
Jazyk:	angličtina
Zdroj:	Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2021; Vol. 432, pp. 89-120.
DOI:	10.1007/978-3-030-83391-6_9
Abstrakt:	Several studies have shown the immunomodulatory effects of extracellular vesicles (EVs) released by pathogenic fungi. Herein, we discuss the data regarding the immunomodulatory properties of fungal EVs, but also of EVs produced by infected leukocytes. This characterizes a two-way path, in which both host and fungal EVs could coexist and play crucial roles in disease progression or protection in fungal infections. We suggest that EVs can dictate the progress of fungal diseases, and their potential as therapeutic targets. (© 2021. Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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