Mitochondrial function influences expression of methamphetamine-induced behavioral sensitization.

Autor: Calma ID; Departments of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.; Center for Compulsive Behavior and Addiction, Rush University Medical Center, Chicago, IL, 60612, USA., Persons AL; Departments of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.; Departments of Physician Assistant Studies, Rush University Medical Center, Chicago, IL, 60612, USA.; Center for Compulsive Behavior and Addiction, Rush University Medical Center, Chicago, IL, 60612, USA., Napier TC; Departments of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, 60612, USA. Celeste_Napier@rush.edu.; Center for Compulsive Behavior and Addiction, Rush University Medical Center, Chicago, IL, 60612, USA. Celeste_Napier@rush.edu.; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Suite 424, Cohn Research Building, 1735 W. Harrison Street, Chicago, IL, 60610, USA. Celeste_Napier@rush.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Dec 31; Vol. 11 (1), pp. 24529. Date of Electronic Publication: 2021 Dec 31.
DOI: 10.1038/s41598-021-04301-9
Abstrakt: Repeated methamphetamine use leads to long lasting brain and behavioral changes in humans and laboratory rats. These changes have high energy requirements, implicating a role for mitochondria. We explored whether mitochondrial function underpins behaviors that occur in rats months after stopping methamphetamine self-administration. Accordingly, rats self-administered intravenous methamphetamine for 3 h/day for 14 days. The mitochondrial toxin rotenone was administered as (1 mg/kg/day for 6 days) via an osmotic minipump starting at 0, 14 or 28 days of abstinence abstinence. On abstinence day 61, expression of methamphetamine-induced behavioral sensitization was obtained with an acute methamphetamine challenge in rotenone-free rats. Rotenone impeded the expression of sensitization, with the most robust effects obtained with later abstinence exposure. These findings verified that self-titration of moderate methamphetamine doses results in behavioral (and thus brain) changes that can be revealed months after exposure termination, and that the meth-initiated processes progressed during abstinence so that longer abstinence periods were more susceptible to the consequences of exposure to a mitochondrial toxin.
(© 2021. The Author(s).)
Databáze: MEDLINE
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