[ 18 F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo.

Autor:	Solingapuram Sai KK; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Chen X; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Li Z; Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA., Zhu C; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Shukla K; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Forshaw TE; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Wu H; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Vance SA; Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA., Pathirannahel BL; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Madonna M; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Dewhirst MW; Department of Radiation Oncology, Duke University, Durham, NC, USA., Tsang AW; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Poole LB; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Ramanujam N; Department of Biomedical Engineering, Duke University, Durham, NC, USA., King SB; Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA., Furdui CM; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: cfurdui@wakehealth.edu.
Jazyk:	angličtina
Zdroj:	Redox biology [Redox Biol] 2022 Feb; Vol. 49, pp. 102218. Date of Electronic Publication: 2021 Dec 18.
DOI:	10.1016/j.redox.2021.102218
Abstrakt:	Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation. Here we take the first step towards this goal and describe the synthesis and kinetic properties of a new positron emission tomography (PET) [ 18 F]Fluoro-DCP radiotracer for in vivo imaging of protein sulfenylation. Time course biodistribution and PET/CT studies using xenograft animal models of Head and Neck Squamous Cell Cancer (HNSCC) demonstrate its capability to distinguish between tumors with radiation sensitive and resistant phenotypes consistent with previous reports of decreased protein sulfenylation in clinical specimens of radiation resistant HNSCC. We envision further development of this technology to aid research efforts towards improving diagnosis of patients with radiation resistant tumors. (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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