Different Patterns of Foods Triggering FPIES in Germany.

Autor:	Lange L; Department of Pediatrics, St. Marien-Hospital, Bonn, Germany. Electronic address: Lars.Lange@gfo-kliniken-bonn.de., Gernert S; Department of Pediatrics, St. Marien-Hospital, Bonn, Germany., Berger M; Department of Medical Biometry, Informatics and Epidemiology, Faculty of Medicine, University of Bonn, Bonn, Germany., Arens A; Pediatric Dermatology and Allergology, Children's Hospital Auf der Bult, Hannover, Germany., Rache L; Nutrition Therapy Praxis, Aachen, Germany., Delissen J; Department of Paediatrics, Children's Hospital Amsterdamer Straße, Cologne, Germany., Yavuz ST; Department of Pediatric Allergy, Childen's Hospital, University of Bonn, Bonn, Germany., Millner-Uhlemann M; Pediatric Praxis, Stuttgart, Germany., Wiesenäcker D; Department of Pediatrics, Kinderklinik München Schwabing, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Neustädter I; Department of Pediatrics and Pediatric Intensive Care, Cnopfsche Kinderklinik, Nuremberg, Germany., Reese I; Dietary Counseling and Nutrition Therapy Centre, Munich, Germany., Utz P; Children's University Hospital, Tuebingen, Germany., Schuster A; Department of Paediatrics, University Hospital, Düsseldorf, Germany., Adelsberger D; Department of Pediatric Pneumology and Allergology, Klinikum Oldenburg, Medical Campus of University Oldenburg, Oldenburg, Germany., Ziegert M; Department of Pediatric Allergology, German Red Cross Hospital, Berlin, Germany., Kerzel S; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg, St. Hedwig Campus, Regensburg, Germany., Finger A; Department of Pediatrics, St. Marien-Hospital, Bonn, Germany.
Jazyk:	angličtina
Zdroj:	The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2022 Apr; Vol. 10 (4), pp. 1063-1069. Date of Electronic Publication: 2021 Dec 20.
DOI:	10.1016/j.jaip.2021.11.033
Abstrakt:	Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food allergy mainly affecting infants and young children. Allergic FPIES reactions differ from IgE-mediated food allergies, for example, regarding elicitors and clinical course. Objective: The aim of our study was to describe causative agents and development of tolerance in German children with FPIES. Methods: We conducted a retrospective survey on children with FPIES from 14 centers in Germany assessing a 6-year period. Results: We analyzed 142 patients with 190 FPIES reactions, 130 of which met acute FPIES criteria and 60 were defined as chronic FPIES. The most frequent eliciting food for acute FPIES was cow's milk, followed by fish, vegetables (eg, potato, pumpkin), meats (eg, beef), and grains. A total of 119 children reacted to 1 food only, 16 children to 2 or 3 foods, and 7 children to ≥4 foods. In chronic FPIES, all but 4 exclusively breastfed infants reacted to cow's milk feeding. IgE sensitization to the triggering food was found in 21 of 152 (14%) cases. Two children developed additional IgE-mediated symptoms upon a food challenge. Time to proof of tolerance was shortest in cow's milk-induced FPIES, and it was shorter in chronic than in acute FPIES. Conclusion: In our national survey, we identified triggers for acute FPIES that partially differ from those reported internationally. Mainly foods introduced early in infant nutrition triggered acute reactions. Time to proven tolerance was shown to be contingent on FPIES symptomatology and on the triggering food. These data should be considered regarding nutritional advice for infants with FPIES. (Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu