IVF protocol efficacy in women with expected suboptimal response depending on ovary stimulation mode.

Autor: Ob'edkova KV; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Kogan IY; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia.; FSBEI of HE St. Petersburg State University, St. Petersburg, Russia., Muller VC; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Tapilskaya NI; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia.; FSBEI of HE St. Petersburg State Pediatriс Medical University under The Ministry of Healthcare of the Russian Federation, St. Petersburg, Russia., Krikhely IO; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Dzhemlikhanova LK; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia.; FSBEI of HE St. Petersburg State University, St. Petersburg, Russia., Abdulkadirova ZK; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia.; FSBEI of HE St. Petersburg State University, St. Petersburg, Russia., Mekina ID; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Lesik EA; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Komarova EA; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Ishchuk MA; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia., Gzgzian AM; FSBSI 'The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott', St. Petersburg, Russia.; FSBEI of HE St. Petersburg State University, St. Petersburg, Russia.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021; Vol. 37 (sup1), pp. 44-48.
DOI: 10.1080/09513590.2021.2006526
Abstrakt: Investigation Objective: IVF protocol efficacy estimation in women with expected suboptimal response depending on ovary stimulation mode.
Materials and Technique: A randomized controlled study embracing results of 51 IVF cycle in women with ovary suboptimal response. The suboptimal response prognostic analysis was performed basing on ≤9 oocyte cumulus complexes obtained in previous IVF programs, the presence of no less than 5-9 antral follicles in both oocytes and amount of anti-Mullerian Hormone ≥0,8 ng/mL. In Group I ( n  = 25), the stimulation was performed by recombinant corifollitropin alfa combined with highly purified urinary gonadotropin, while in Group II ( n  = 26) it was made by means of recombinant follitropin/lutropin alfa within the protocol of applying gonadotropin-releasing hormone antagonists.
Results: The total gonadotropin dose in Group II patients was authentically lower compared to Group I ( p ˂,01). No statistical difference between the two studied groups was detected concerning the number of obtained oocytes, 2pn zygote, good-quality transferred embryos and clinical pregnancy rate ( p >.05). Embryo cryopreservation was performed only for group-II patients.
Conclusion: Corifollitropin alfa administration combined with highly purified menotropin in IVF cycles for suboptimal responders is quite effective, however, this strategy has no preference over other stimulation modes. The strategy of using recombinant follitropin/lutropin alfa can be promotive to IVF outcomes for suboptimal responders by means of embryo banking. ClinicalTrials.gov Identifier: NCT03177538.
Databáze: MEDLINE
Externí odkaz: