Latin Americans and US Hispanics show differences in IBD phenotype: a systematic review with meta-analysis.

Autor:	Avalos DJ; Gastroenterology, Miami Gastro LLC, Homestead, Florida, USA djavalos@gmail.com., Satiya J; Division of Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Contreras A; Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, Texas, USA., Trivedi S; Department of Internal Medicine, Largo Medical Center, Largo, Florida, USA., Alvarado L; Biostatistics and Epidemiology Consulting lab, Texas Tech University Health Sciences Center, El Paso, Texas, USA., Dodoo C; Biostatistics and Epidemiology Consulting lab, Texas Tech University Health Sciences Center, El Paso, Texas, USA., Dwivedi AK; Department of Molecular and Translational Medicine, Division of Biostatistics & Epidemiology, Texas Tech University Health Sciences Center, El Paso, Texas, USA., Zuckerman MJ; Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, Texas, USA.
Jazyk:	angličtina
Zdroj:	Journal of investigative medicine : the official publication of the American Federation for Clinical Research [J Investig Med] 2022 Apr; Vol. 70 (4), pp. 919-933. Date of Electronic Publication: 2021 Dec 21.
DOI:	10.1136/jim-2021-001846
Abstrakt:	Latin America has experienced a rise in the prevalence and incidence of inflammatory bowel disease (IBD). Differences in IBD phenotype between Hispanics in Latin America and those in the USA have not been described. We conducted a systematic review with meta-analysis of population-based and cohort studies comparing the phenotype of ulcerative colitis (UC) and Crohn's disease (CD) in Latin Americans and US Hispanics. A systematic search was conducted up to March 2019 using MEDLINE, EMBASE and Google Scholar. Inclusion criterion includes studies describing IBD phenotype in Latin Americans or in US Hispanics. Exclusion criterion includes prevalence or incidence studies not describing phenotype. A random effects model was chosen "a priori" for analysis of pooled proportions. A total of 46 studies were included from Latin America and 7 studies from the USA. The predominant IBD subtype in Latin America was UC with a more balanced UC:CD ratio noted in Puerto Rico (0.53) and Brazil (0.56). UC-related extensive colitis was more common in US Hispanics (0.64) than in Latin Americans (0.38), p<0.001. CD phenotype was similar between US Hispanics and Latin Americans. UC is the predominant IBD subtype in Latin America, with the exception of Puerto Rico and Brazil which demonstrate a more balanced UC:CD ratio. In UC, extensive colitis was more frequently seen in US Hispanics than in Latin Americans. CD phenotype was similar in both US Hispanics and Latin Americans. Competing Interests: Competing interests: AKD is an Associate Editor for the Journal of Investigative Medicine. (© American Federation for Medical Research 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu