| Autor: |
Batista TSC; Universidade Federal de Sergipe, Departamento de Fisioterapia, Lagarto, SE, Brasil.; Universidade Federal de Sergipe, Centro de Ciências Biológicas e da Saúde, Departamento de Biologia, Laboratório de Genética Molecular e Biotecnologia - GMBio, São Cristóvão, SE, Brasil., Barros GS; Universidade Federal de Sergipe, Centro de Ciências Biológicas e da Saúde, Departamento de Biologia, Laboratório de Genética Molecular e Biotecnologia - GMBio, São Cristóvão, SE, Brasil., Damasceno FC; Universidade Federal de Sergipe, Departamento de Química, São Cristóvão, SE, Brasil., Cândido EAF; Universidade Tiradentes, Instituto de Tecnologia e Pesquisa, Aracaju, SE, Brasil., Batista MVA; Universidade Federal de Sergipe, Centro de Ciências Biológicas e da Saúde, Departamento de Biologia, Laboratório de Genética Molecular e Biotecnologia - GMBio, São Cristóvão, SE, Brasil. |
| Abstrakt: |
This study evaluated the effect of the volatile oil of Alpinia zerumbet (VOAz) on caveolin-1 gene expression and muscular fibrosis. The rats were immobilized to induce fibrosis of the gastrocnemius muscle, and they were treated with VOAz. Collagen quality was assessed by histology and the expression of the caveolin-1 (CAV-1) gene was evaluated using qPCR. Histomorphological analysis indicated a significant reduction in the perimeter, width, and intensity of collagen in the treated groups, thus showing that the oil was effective in regulating the quality of collagen at the three concentrations. The results of expression levels suggested a decrease in the lesioned group and in two treatment groups (0.0115 µg/g and 0.009 µg/g). However, with the lowest concentration (0.0065 µg/g), no significant difference was observed, with levels similar to those found in healthy tissue. Therefore, the results showed that VOAz has the potential to be a non-invasive and low-cost alternative to aid in the treatment of muscular fibrosis. |
